دورية أكاديمية
The trajectory of functional status of patients with kidney failure choosing conservative kidney management.
| العنوان: | The trajectory of functional status of patients with kidney failure choosing conservative kidney management. |
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| المؤلفون: | Doorn WB; Department of Elderly Psychiatry, Altrecht, Utrecht, The Netherlands. wouterdoorn@gmail.com., van Loon IN; Dianet Dialysis Center, Utrecht, The Netherlands., Boereboom FTJ; Dianet Dialysis Center, Utrecht, The Netherlands.; Department of Internal Medicine, Diakonessenhuis Utrecht, Utrecht, The Netherlands., Hamaker ME; Department of Geriatrics, Diakonessenhuis Utrecht, Utrecht, The Netherlands., Goto NA; Dianet Dialysis Center, Utrecht, The Netherlands.; Department of Geriatrics, Jeroen Bosch Hospital, `S-Hertogenbosch, The Netherlands. |
| المصدر: | International urology and nephrology [Int Urol Nephrol] 2024 Jul 16. Date of Electronic Publication: 2024 Jul 16. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Springer Original Publication: Budapest, Akademiai Kiadó |
| مستخلص: | Purpose: In older patients with kidney failure (KF) starting dialysis, there is a high rate of functional decline. Not much is known about the functional trajectory of patients receiving conservative kidney management (CKM). Therefore, the aim of this study is to assess this functional trajectory and explore clinical parameters associated with functional decline. Methods: The functional trajectory of patients choosing CKM was evaluated using data from the Geriatric Assessment in Older Patients Starting Dialysis (GOLD) study, which included patients aged ≥ 65 years with KF at the moment of decision-making. Functional status was assessed using a combined score for activities of daily living (ADL) and instrumental activities of daily living (iADL) dependency at baseline and after six months of follow-up. Change in functional status was divided into improvement (gain of one or more domains in functional status), stable (no change), decline (loss of one or more domains in functional status), and death at follow-up. The association between functional status at baseline and functional decline after six months was assessed with chi-squared test or Fisher's exact test. Furthermore, caregiver experiences were explored using self perceived pressure of informal care (SPPIC) at baseline and 6-month follow-up. Results: Follow-up data were available for 86 patients. Mean age was 82 ± 6 years and 43% were women. At baseline, 12% of the patients were independent, 55% were mild/moderately dependent, and 34% severely dependent. After 6 months of follow-up, 9% of all patients had improved, 35% remained stable, 41% had declined, and 15% had died. No significant associations were found between baseline characteristics and the composite outcomes. Conclusion: In patients aged ≥ 65 years receiving CKM, functional decline and death are highly prevalent. No association was found between poor outcome ("decline/death") and different potential risk factors. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.) |
| References: | Hill NR et al (2016) Global prevalence of chronic kidney disease—a systematic review and meta-analysis. PLoS ONE. https://doi.org/10.1371/journal.pone.0158765. (PMID: 10.1371/journal.pone.0158765280333995198985) Davison SN et al (2024) Conservative kidney management and kidney supportive care: core components of integrated care for people with kidney failure. Kidney Int 105(1):35–45. https://doi.org/10.1016/j.kint.2023.10.001. (PMID: 10.1016/j.kint.2023.10.00138182300) United States Renal Data System, “2023 USRDS Annual Data Report: Epidemiology of kidney disease in the United States,” National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Nefrovisie, 1RENINE annual report 2019. [Online]. https://www.nefrovisie.nl/wp-content/uploads/2021/01/Jaarrapport_Renine19.pdf. Nefrovisie, “Nefrodata 2020.” [Online]. https://ivisualz.nl/ivisualz/chartFlash/charts. Goto NA et al (2019) Geriatric assessment in elderly patients with end-stage kidney disease. Nephron. https://doi.org/10.1159/000494222. (PMID: 10.1159/00049422231408861) van Loon IN, Wouters TR, Boereboom FTJ, Bots ML, Verhaar MC, Hamaker ME (2016) The relevance of geriatric impairments in patients starting dialysis: a systematic review. Clin J Am Soc Nephrol. https://doi.org/10.2215/CJN.06660615. (PMID: 10.2215/CJN.06660615271175814934838) Kallenberg MH et al (2016) Functional and cognitive impairment, frailty, and adverse health outcomes in older patients reaching ESRD-a systematic review. Clin J Am Soc Nephrol. https://doi.org/10.2215/CJN.13611215. (PMID: 10.2215/CJN.13611215273425985012494) Brown EA (2015) Maximal conservative management. Medicine 43(8):493–495. https://doi.org/10.1016/j.mpmed.2015.05.012. (PMID: 10.1016/j.mpmed.2015.05.012) Verberne WR et al (2021) Health-related quality of life and symptoms of conservative care versus dialysis in patients with end-stage kidney disease: A systematic review. Nephrol Dial Transplant. https://doi.org/10.1093/ndt/gfaa078. (PMID: 10.1093/ndt/gfaa078338906698476077) Chou A, Li KC, Brown MA (2022) Survival of older patients with advanced CKD managed without dialysis: a narrative review. Kidney Med 4(5):100447. https://doi.org/10.1016/j.xkme.2022.100447. (PMID: 10.1016/j.xkme.2022.100447354981599046625) Verberne WR et al (2018) Value-based evaluation of dialysis versus conservative care in older patients with advanced chronic kidney disease: a cohort study. BMC Nephrol. https://doi.org/10.1186/s12882-018-1004-4. (PMID: 10.1186/s12882-018-1004-4301150286097302) W. R. Verberne, A. B. M. Tom Geers, W. T. Jellema, H. H. Vincent, J. J. M. van Delden, and W. J. W. Bos, “Comparative survival among older adults with advanced kidney disease managed conservatively versus with dialysis,” Clin J Am Soc Nephrol, 2016. https://doi.org/10.2215/CJN.07510715 . Misra M, Oreopoulos D, Vonesh E (2008) Dialysis or not? A comparative survival study of patients over 75 years of age with chronic kidney disease stage 5. Neprhol Dial Transplant. https://doi.org/10.1093/ndt/gfm881. (PMID: 10.1093/ndt/gfm881) Shah KK et al (2019) Health-related quality of life and well-being in people over 75 years of age with end-stage kidney disease managed with dialysis or comprehensive conservative care: a cross-sectional study in the UK and Australia. BMJ Open. https://doi.org/10.1136/bmjopen-2018-027776. (PMID: 10.1136/bmjopen-2018-027776318748687008410) Ramer SJ et al (2018) Health outcome priorities of older adults with advanced CKD and concordance with their nephrology providers’ perceptions. J Am Soc Nephrol. https://doi.org/10.1681/ASN.2018060657. (PMID: 10.1681/ASN.2018060657303856526287864) Goto NA et al (2019) Association of initiation of maintenance dialysis with functional status and caregiver burden. Clin J Am Soc Nephrol. https://doi.org/10.2215/CJN.13131118. (PMID: 10.2215/CJN.13131118312489486625621) M. Kurella Tamura, K. E. Covinsky, G. M. Chertow, K. Yaffe, C. S. Landefeld, and C. E. McCulloch, “Functional Status of Elderly Adults before and after Initiation of Dialysis,” New England Journal of Medicine, 2009, https://doi.org/10.1056/nejmoa0904655 . Bossola M, Marino C, Di Napoli A, Agabiti N, Tazza L, Davoli M (2018) Functional impairment and risk of mortality in patients on chronic hemodialysis: results of the Lazio Dialysis Registry. J Nephrol. https://doi.org/10.1007/s40620-018-0484-4. (PMID: 10.1007/s40620-018-0484-429572627) Murtagh FEM, Addington-Hall JM, Higginson IJ (2011) End-stage renal disease: a new trajectory of functional decline in the last year of life. J Am Geriatr Soc. https://doi.org/10.1111/j.1532-5415.2010.03248.x. (PMID: 10.1111/j.1532-5415.2010.03248.x21275929) Kilshaw L, Sammut H, Asher R, Williams P, Saxena R, Howse M (2016) A study to describe the health trajectory of patients with advanced renal disease who choose not to receive dialysis. Clin Kidney J. https://doi.org/10.1093/ckj/sfw005. (PMID: 10.1093/ckj/sfw005272748354886902) Verberne WR et al (2019) Older patients’ experiences with a shared decision-making process on choosing dialysis or conservative care for advanced chronic kidney disease: a survey study. BMC Nephrol. https://doi.org/10.1186/s12882-019-1423-x. (PMID: 10.1186/s12882-019-1423-x313115116635995) S. Katz, A. B. Ford, R. W. Moskowitz, B. A. Jackson, and M. W. Jaffe, “Studies of Illness in the Aged: The Index of ADL: A Standardized Measure of Biological and Psychosocial Function,” JAMA: The Journal of the American Medical Association, vol. 185, no. 12, pp. 914–919, 1963, https://doi.org/10.1001/jama.1963.03060120024016 . Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186. https://doi.org/10.1093/geront/9.3_Part_1.179. (PMID: 10.1093/geront/9.3_Part_1.1795349366) Richardson S (1991) The Timed ‘Up & Go’: A Test of Basic Functional Mobility for Frail Elderly Persons. J Am Geriatr Soc 39(2):142–148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x. (PMID: 10.1111/j.1532-5415.1991.tb01616.x1991946) Yesavage JA (1988) Geriatric Depression Scale. Psychopharmacol Bull 24(4):709–710. https://doi.org/10.1007/978-3-319-69892-2_736-1. (PMID: 10.1007/978-3-319-69892-2_736-13249773) Marc LG, Raue PJ, Bruce ML (2008) Screening performance of the 15-item geriatric depression scale in a diverse elderly home care population. Am J Geriatric Psychiatry 16(11):914–921. https://doi.org/10.1097/JGP.0b013e318186bd67. (PMID: 10.1097/JGP.0b013e318186bd67) Guigoz Y, Vellas B (1999) The Mini Nutritional Assessment (MNA) for grading the nutritional state of elderly patients: presentation of the MNA, history and validation. Nestle Nutr Workshop Ser Clin Perform Programme 1:2–3. https://doi.org/10.1159/000062967. (PMID: 10.1159/000062967) Miller MD et al (1992) Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale. Psychiatry Res 41(3):237–248. https://doi.org/10.1016/0165-1781(92)90005-N. (PMID: 10.1016/0165-1781(92)90005-N1594710) Folstein MF, Folstein SE, McHugh PR (1975) ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198. https://doi.org/10.1016/0022-3956(75)90026-6. (PMID: 10.1016/0022-3956(75)90026-61202204) B. Schmand, P. Houx, and I. de Koning, “The stroop colour word test, the trail making test, the Rivermead behavioural memory test. Dutch norms,” Netherlands Institute of Psychologists, Section of …, 2004. Royall DR, Cordes JA, Polk M (1998) CLOX: An executive clock drawing task. J Neurol Neurosurg Psychiatry 64(5):588–594. https://doi.org/10.1136/jnnp.64.5.588. (PMID: 10.1136/jnnp.64.5.58895986722170069) Grober E, Buschke H, Crystal H, Bang S, Dresner R (1988) Screening for dementia by memory testing. Neurology 38(6):900–903. https://doi.org/10.1212/wnl.38.6.900. (PMID: 10.1212/wnl.38.6.9003368071) Fried LP et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol—Ser A Biol Sci Med Sci 56(3):M146–M156. https://doi.org/10.1093/gerona/56.3.m146. (PMID: 10.1093/gerona/56.3.m146) Lunney JR, Lynn J, Hogan C (2002) Profiles of older medicare decedents. J Am Geriatr Soc 50(6):1108–1112. https://doi.org/10.1046/j.1532-5415.2002.50268.x. (PMID: 10.1046/j.1532-5415.2002.50268.x12110073) de Boer AH, Oudijk D, Timmermans JM, Pot AM (2012) Self perceived burden from informal care: construction of the EDIZ-plus. Tijdschr Gerontol Geriatr 43(2):77–88. https://doi.org/10.1007/s12439-012-0010-4. (PMID: 10.1007/s12439-012-0010-422642048) Teunisse S, Derix MMA (1997) The interview for deterioration in daily living activities in dementia: agreement between primary and secondary caregivers. Int Psychogeriatr. https://doi.org/10.1017/s1041610297004845. (PMID: 10.1017/s10416102970048459447438) Goto NA et al (2019) Association of initiation of maintenance dialysis with functional status and caregiver burden. Clin J Am Soc Nephrol 14(7):1039–1047. (PMID: 10.2215/CJN.13131118312489486625621) Hall RK, McAdams-DeMarco MA (2018) Breaking the cycle of functional decline in older dialysis patients. Semin Dial 31(5):462–467. (PMID: 10.1111/sdi.12695296422686175658) C. M. Rhee, D. v. Nguyen, A. Nyamathi, and K. Kalantar-Zadeh, “Conservative vs. preservative management of chronic kidney disease: Similarities and distinctions,” Current Opinion in Nephrology and Hypertension. 2020. https://doi.org/10.1097/MNH.0000000000000573 . Jassal SV, Chiu E, Hladunewich M (2009) Loss of independence in patients starting dialysis at 80 years of age or older. N Engl J Med 361(16):1612–1613. https://doi.org/10.1056/NEJMc0905289. (PMID: 10.1056/NEJMc090528919828543) van Loon IN, Goto NA, Boereboom FTJ, Verhaar MC, Bots ML, Hamaker ME (2019) Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study. BMC Nephrol. https://doi.org/10.1186/s12882-019-1268-3. (PMID: 10.1186/s12882-019-1268-3309222466440027) |
| فهرسة مساهمة: | Keywords: Conservative kidney management; Functional status; Kidney failure; Older patients |
| تواريخ الأحداث: | Date Created: 20240716 Latest Revision: 20240716 |
| رمز التحديث: | 20240716 |
| DOI: | 10.1007/s11255-024-04154-x |
| PMID: | 39012581 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2584 |
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| DOI: | 10.1007/s11255-024-04154-x |