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Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses.

التفاصيل البيبلوغرافية
العنوان: Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses.
المؤلفون: Renklint R; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden rebeckarenklint@hotmail.com., Chninou Y; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden., Heni M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University Tübingen, Tübingen, Germany.; Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital of Tübingen, Tübingen, Germany., Fritsche A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University Tübingen, Tübingen, Germany.; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany., Haering HU; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany., Wagner R; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany.; Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, German Diabetes Center, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Otten J; Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
المصدر: BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2024 Jul 16; Vol. 12 (4). Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article; Systematic Review; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: Published by BMJ in partnership with the American Diabetes Association Country of Publication: England NLM ID: 101641391 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4897 (Electronic) Linking ISSN: 20524897 NLM ISO Abbreviation: BMJ Open Diabetes Res Care Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Published by BMJ in partnership with the American Diabetes Association
مواضيع طبية MeSH: Glucose Tolerance Test*/methods , Insulin Secretion* , Insulin*/blood , Insulin*/metabolism , Glucose Clamp Technique* , Blood Glucose*/analysis , Diabetes Mellitus, Type 2*/blood, Humans ; Biomarkers/analysis ; Biomarkers/blood ; Insulin Resistance ; Prediabetic State/diagnosis ; Prediabetic State/blood
مستخلص: Introduction: In this systematic review, we investigated the diagnostic accuracy of surrogate measures of insulin secretion based on fasting samples and the oral glucose tolerance test (OGTT). The first phase of insulin secretion was calculated using two gold standard methods; the hyperglycemic clamp (HGC) test and intravenous glucose tolerance test (IVGTT).
Research Design and Methods: We conducted searches in the PubMed, Cochrane Central, and Web of Science databases, the last of which was conducted at the end of June 2021. Studies were included that measured first-phase insulin secretion in adults using both a gold-standard reference method (either HGC or IVGTT) and one or more surrogate measures from either fasting samples, OGTT or a meal-tolerance test. QUADAS-2, a revised tool for the quality assessment of diagnostic accuracy studies, was used for quality assessment. Random-effects meta-analyses were performed to examine the correlation between first-phase measured with gold standard and surrogate methods.
Results: A total of 33 articles, encompassing 5362 individuals with normal glucose tolerance, pre-diabetes or type 2 diabetes, were included in our systematic review. Homeostatic model assessment (HOMA)-beta and Insulinogenic Index 30 (IGI(30)) were the surrogate measures validated in the largest number of studies (17 and 13, respectively). HOMA-beta's pooled correlation to the reference methods was 0.48 (95% CI 0.40 to 0.56) The pooled correlation of IGI to the reference methods was 0.61 (95% CI 0.54 to 0.68). The surrogate measures with the highest correlation to the reference methods were Kadowaki (0.67 (95% CI 0.61 to 0.73)) and Stumvoll's first-phase secretion (0.65 (95% CI 0.58 to 0.71)), both calculated from an OGTT.
Conclusions: Surrogate measures from the first 30 min of an OGTT capture the first phase of insulin secretion and are a good choice for epidemiological studies. HOMA-beta has a moderate correlation to the reference methods but is not a measure of the first phase specifically.
Prospero Registration Number: The meta-analysis was registered at PROSPERO (Id: CRD42020169064) before inclusion started.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: Insulin Secretion
المشرفين على المادة: 0 (Insulin)
0 (Blood Glucose)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240726
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11268049
DOI: 10.1136/bmjdrc-2024-004256
PMID: 39013634
قاعدة البيانات: MEDLINE
الوصف
تدمد:2052-4897
DOI:10.1136/bmjdrc-2024-004256