دورية أكاديمية
أعرض في EDS

Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial.
المؤلفون: Wen X; Department of Anesthesiology and Operation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Wang L; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. wangli811125@163.com., Li F; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Yu X; Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
المصدر: Journal of ovarian research [J Ovarian Res] 2024 Jul 16; Vol. 17 (1), pp. 147. Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2008-
مواضيع طبية MeSH: Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/blood , Polycystic Ovary Syndrome*/metabolism , Vitamin D*/blood , Vitamin D*/therapeutic use , Dietary Supplements* , Insulin Resistance*, Humans ; Female ; Adult ; Young Adult ; Body Mass Index ; Insulin/blood ; Waist-Hip Ratio ; Glucose Tolerance Test
مستخلص: Objective: The aim of this study was to explore the effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome (PCOS).
Methods: A total of 60 PCOS women with vitamin D deficiency or insufficiency were enrolled in this randomized controlled trial. Participants were randomized to vitamin D group (2000 IU/day) or control group. The observational parameters were measured at baseline and after treatment, including body mass index (BMI), waist to hip ratio (WHR), oral glucose tolerance test (OGTT) and insulin release test, and lipid metabolism parameters.
Results: The serum 25(OH)D concentrations at different time points after vitamin D supplementation were significantly higher than that in control group (P < 0.05). The BMI, WHR, insulin concentrations, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations in women of Vitamin D group after 12 weeks of treatment were significantly lower than that in women of control group (P < 0.05). The serum insulin concentrations and HOMA-IR at different time points of OGTT, serum TG, TC and LDL-C concentrations in women of vitamin D group (obesity) were significantly lower compared with control group (obesity) (P < 0.05). The BMI, WHR, TG, TC and LDL-C concentration in women of vitamin D group (IR) were significantly lower compared with control group (IR) (P < 0.05). No significant difference was observed in metabolic parameters between vitamin D group (non-obesity) and control group (non-obesity) (P > 0.05), and these differences of metabolic parameters were also not observed between vitamin D group (non-IR) and control group (non-IR) (P > 0.05).
Conclusion: Vitamin D supplementation had beneficial effects on metabolic parameters in PCOS women, especially in women with obesity or insulin resistance.
(© 2024. The Author(s).)
References: Nutrients. 2019 Jan 17;11(1):. (PMID: 30658483)
Gynecol Endocrinol. 2020 Jan;36(1):1-5. (PMID: 31187648)
Front Endocrinol (Lausanne). 2023 Mar 09;14:1110341. (PMID: 36967791)
Afr Health Sci. 2020 Dec;20(4):1880-1886. (PMID: 34394253)
Trends Cardiovasc Med. 2020 Oct;30(7):399-404. (PMID: 31519403)
Nutrients. 2019 Apr 06;11(4):. (PMID: 30959886)
Nutr Res. 2012 Mar;32(3):195-201. (PMID: 22464806)
Nutrients. 2015 Jun 08;7(6):4555-77. (PMID: 26061015)
Diabetol Metab Syndr. 2023 Apr 19;15(1):76. (PMID: 37072813)
N Engl J Med. 2016 Aug 11;375(6):523-33. (PMID: 27509101)
Endocrine. 2020 Jan;67(1):1-8. (PMID: 31538291)
Clin Nutr. 2015 Aug;34(4):586-92. (PMID: 25300649)
Biochim Biophys Acta. 2008 Feb;1780(2):264-73. (PMID: 18082637)
J Cell Biochem. 2019 Jun;120(6):10337-10341. (PMID: 30556194)
Cell. 2018 May 17;173(5):1135-1149.e15. (PMID: 29754817)
Nutr J. 2013 Jan 08;12:8. (PMID: 23297844)
Front Endocrinol (Lausanne). 2020 Mar 31;11:171. (PMID: 32296394)
Eur J Nutr. 2019 Aug;58(5):2019-2028. (PMID: 29946756)
J Clin Endocrinol Metab. 2023 Sep 18;108(10):2447-2469. (PMID: 37580314)
J Steroid Biochem Mol Biol. 2018 Jan;175:177-189. (PMID: 27662816)
Hepatology. 2020 May;71(5):1559-1574. (PMID: 31506976)
Nutrients. 2018 Nov 02;10(11):. (PMID: 30400199)
Nutr Res Rev. 2017 Jun;30(1):97-105. (PMID: 28222828)
Reprod Biol Endocrinol. 2022 Jun 29;20(1):95. (PMID: 35768803)
J Clin Endocrinol Metab. 2020 Dec 1;105(12):. (PMID: 32844212)
J Ovarian Res. 2023 Jan 11;16(1):9. (PMID: 36631836)
J Obstet Gynaecol India. 2017 Oct;67(5):349-355. (PMID: 28867886)
Cell Chem Biol. 2017 Feb 16;24(2):207-217. (PMID: 28132894)
Biol Pharm Bull. 2005 Aug;28(8):1418-23. (PMID: 16079486)
J Reprod Med. 2017 May-Jun;62(5-6):300-4. (PMID: 30027724)
Phytother Res. 2023 Jun;37(6):2315-2325. (PMID: 36724890)
Climacteric. 2024 Feb;27(1):47-52. (PMID: 38073517)
Heliyon. 2023 Feb 26;9(3):e13991. (PMID: 36923858)
Front Endocrinol (Lausanne). 2021 Aug 19;12:610893. (PMID: 34489860)
Ann Med Surg (Lond). 2023 Jun 5;85(7):3506-3511. (PMID: 37427232)
معلومات مُعتمدة: No. 2022SF-163 The Social Development Project of Key Research and Development Program of Shaanxi Province, China
فهرسة مساهمة: Keywords: Insulin resistance; Metabolic diseases; Obesity; Polycystic ovary syndrome; Vitamin D; Vitamin D deficiency
المشرفين على المادة: 1406-16-2 (Vitamin D)
0 (Insulin)
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240717 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11251207
DOI: 10.1186/s13048-024-01473-6
PMID: 39014475
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-2215
DOI:10.1186/s13048-024-01473-6