دورية أكاديمية
أعرض في EDS

Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns.

التفاصيل البيبلوغرافية
العنوان: Bacterial nanocellulose/calcium alginate hydrogel for the treatment of burns.
المؤلفون: Munhoz LLS; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Guillens LC; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Alves BC; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Nascimento MGOFD; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Meneguin AB; Universidade Estadual de São Paulo - School of Pharmaceutical Sciences, Araraquara (SP), Brasil., Carbinatto FM; Universidade de Araraquara - BioPolymer and Biomaterial Laboratory, Araraquara (SP), Brazil.; Universidade de São Paulo - Institute of Physics, São Carlos (SP), Brasil., Arruda G; Universidade de Araraquara - BioPolymer and Biomaterial Laboratory, Araraquara (SP), Brazil., Barud HDS; Universidade de Araraquara - BioPolymer and Biomaterial Laboratory, Araraquara (SP), Brazil.; Universidade de São Paulo - Institute of Physics, São Carlos (SP), Brasil., Aro A; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Casagrande LR; Universidade do Extremo Sul Catarinense - Graduate Program in Science of Health - Criciúma (SC), Brazil., Silveira PCL; Universidade do Extremo Sul Catarinense - Graduate Program in Science of Health - Criciúma (SC), Brazil., Andrade TAM; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Santos GMTD; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil., Caetano GF; Centro Universitário Herminio Ometto de Araras - Graduate Program in Biomedical Sciences, Araras (SP), Brazil.; Centro Universitário Herminio Ometto de Araras - Graduate Program of Orthodontics, Araras (SP), Brazil.; Universidade de São Paulo - Ribeirão Preto Medical School, Ribeirão Preto (SP), Brazil.
المصدر: Acta cirurgica brasileira [Acta Cir Bras] 2024 Jul 15; Vol. 39, pp. e393324. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE
أسماء مطبوعة: Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina
Original Publication: São Paulo : A Sociedade,
مواضيع طبية MeSH: Alginates*/therapeutic use , Cellulose*/therapeutic use , Burns*/drug therapy , Burns*/therapy , Wound Healing*/drug effects , Rats, Wistar* , Hydrogels*/therapeutic use, Animals ; Male ; Rats ; Glucuronic Acid/therapeutic use ; Hexuronic Acids/therapeutic use ; Reproducibility of Results ; Viscosity ; Oxidative Stress/drug effects ; Immunohistochemistry ; Time Factors ; Skin/injuries ; Skin/drug effects
مستخلص: Purpose: Bacterial cellulose (BC) has shown high capacity for the treatment of wounds and burns, providing a moisty environment. Calcium alginate can be associated with BC to create gels that aid in wound debridement and contribute to appropriate wound healing. This study is aimed at characterizing and evaluating the use of bacterial cellulose/alginate gel in skin burns in rats.
Methods: Cellulose and cellulose/alginate gels were compared regarding the capacity of liquid absorption, moisture, viscosity, and potential cytotoxicity. The 2nd degree burns were produced using an aluminum metal plate (2.0cm) at 120ºC for 20s on the back of rats. The animals were divided into non-treated, CMC(Carboxymethylcellulose), Cellulose(CMC with bacterial cellulose), and Cellulose/alginate(CMC with bacterial cellulose and alginate). The animals received topical treatment 3 times/week. Biochemical (MPO, NAG and oxidative stress), histomorphometry and immunohistochemical assays (IL-1β IL-10 and VEGF) were conducted on the 14th, 21st, 28th, and 35th days.
Results: Cellulose/Alginate gel showed higher absorption capacity and viscosity compared to Cellulose gel, with no cytotoxic effects. Cellulose/alginate presented lower MPO values, a higher percentage of IL-10, with greater and balanced oxidative stress profile.
Conclusions: The use of cellulose/alginate gel reduced neutrophils and macrophage activation and showed greater anti-inflammatory response, which can contribute to healing chronic wounds and burns.
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المشرفين على المادة: 0 (Alginates)
9004-34-6 (Cellulose)
0 (Hydrogels)
8A5D83Q4RW (Glucuronic Acid)
0 (Hexuronic Acids)
تواريخ الأحداث: Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11249442
DOI: 10.1590/acb393324
PMID: 39016358
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-2674
DOI:10.1590/acb393324