دورية أكاديمية
Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species.
| العنوان: | Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species. |
|---|---|
| المؤلفون: | Machado E; Laboratório de Biologia Molecular Aplicada a Micobactérias, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Vasconcellos S; Laboratório de Biologia Molecular Aplicada a Micobactérias, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Gomes L; Laboratório de Biologia Molecular Aplicada a Micobactérias, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Catanho M; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil., Ramos J; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., de Carvalho L; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Goldenberg T; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Redner P; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Caldas P; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Campos C; Laboratório de Referência Nacional para Tuberculose, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Dalcolmo M; Serviço de Pesquisa Clínica, Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brazil., Lourenço MC; Laboratório de Bacteriologia e Bioensaios, Instituto Nacional de Infectologia, Fiocruz, Rio de Janeiro, RJ, Brazil., Lasunskaia E; Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil., Mussi V; Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil., Spinassé L; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil., Vinhas S; Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil., Rigouts L; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., Cogneau S; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., de Rijk P; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., Utpatel C; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany., Kaustova J; Department of Diagnostic Mycobacterioses, Regional Institute of Public Health, Ostrava, Czech Republic., van der Laan T; National Institute for Public Health and the Environment, Bilthoven, Netherlands., de Neeling H; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Rastogi N; TB and Mycobacteria Unit, Institut Pasteur de Guadeloupe, Guadeloupe, France., Levina K; Mycobacteriology Section of Microbiology Laboratory, North Estonia Medical Centre, Tallinn, Estonia., Kütt M; Mycobacteriology Section of Microbiology Laboratory, North Estonia Medical Centre, Tallinn, Estonia., Mokrousov I; Laboratory of Molecular Epidemiology and Evolutionary Genetics, St. Petersburg Pasteur Institute, St. Petersburg, Russia., Zhuravlev V; St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russia., Makhado N; Department of Microbiological Pathology, Sefako Makgatho Health Sciences University, Pretoria, South Africa.; National Health Laboratory Service, Dr George Mukhari Tertiary Laboratory, Medical Microbiology, Pretoria, South Africa.; Global Institute of Health, University of Antwerp, Antwerp, Belgium.; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., Žolnir-Dovč M; National Reference Laboratory for Mycobacteria, University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia., Jankovic V; Mycobacteria Reference Laboratory, Croatian National Institute of Public Health, Zagreb, Croatia., de Waard J; Tuberculosis Department. Servicio Autónomo Instituto de Biomedicina Dr. Jacinto Convit, Universidad Central de Venezuela, Caracas, Venezuela.; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Sisco MC; Tuberculosis Department. Servicio Autónomo Instituto de Biomedicina Dr. Jacinto Convit, Universidad Central de Venezuela, Caracas, Venezuela., van Soolingen D; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Niemann S; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany., de Jong BC; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., Meehan CJ; Department of Biosciences, Nottingham Trent University, Nottingham, UK.; Unit of Mycobacteriology, Institute of Tropical Medicine, Antwerp, Belgium., Suffys P; Laboratório de Biologia Molecular Aplicada a Micobactérias, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil. |
| المصدر: | Microbial genomics [Microb Genom] 2024 Jul; Vol. 10 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 101671820 Publication Model: Print Cited Medium: Internet ISSN: 2057-5858 (Electronic) Linking ISSN: 20575858 NLM ISO Abbreviation: Microb Genom Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : [London] : Microbiology Society Original Publication: [London] : Society for General Microbiology, [2015]- |
| مواضيع طبية MeSH: | Mycobacterium kansasii*/genetics , Mycobacterium kansasii*/classification , Mycobacterium kansasii*/isolation & purification , Phylogeny* , Genome, Bacterial* , Mycobacterium Infections, Nontuberculous*/microbiology , Genomics*, Humans ; Animals ; Virulence/genetics |
| مستخلص: | Species belonging to the Mycobacterium kansasii complex (MKC) are frequently isolated from humans and the environment and can cause serious diseases. The most common MKC infections are caused by the species M. kansasii ( sensu stricto ), leading to tuberculosis-like disease. However, a broad spectrum of virulence, antimicrobial resistance and pathogenicity of these non-tuberculous mycobacteria (NTM) are observed across the MKC. Many genomic aspects of the MKC that relate to these broad phenotypes are not well elucidated. Here, we performed genomic analyses from a collection of 665 MKC strains, isolated from environmental, animal and human sources. We inferred the MKC pangenome, mobilome, resistome, virulome and defence systems and show that the MKC species harbours unique and shared genomic signatures. High frequency of presence of prophages and different types of defence systems were observed. We found that the M. kansasii species splits into four lineages, of which three are lowly represented and mainly in Brazil, while one lineage is dominant and globally spread. Moreover, we show that four sub-lineages of this most distributed M. kansasii lineage emerged during the twentieth century. Further analysis of the M. kansasii genomes revealed almost 300 regions of difference contributing to genomic diversity, as well as fixed mutations that may explain the M. kansasii 's increased virulence and drug resistance. |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: Mycobacterium kansasii; lineages; pangenome; phylogenomics; virulence |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| مُعرف محوري في PubMed: | PMC11316565 |
| DOI: | 10.1099/mgen.0.001266 |
| PMID: | 39016539 |
| قاعدة البيانات: | MEDLINE |
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