دورية أكاديمية
Exploring the multiple effects of nifedipine and captopril administration in spontaneously hypertensive rats through pharmacokinetic-pharmacodynamic analyses.
العنوان: | Exploring the multiple effects of nifedipine and captopril administration in spontaneously hypertensive rats through pharmacokinetic-pharmacodynamic analyses. |
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المؤلفون: | Kiriyama A; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan., Kimura S; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan., Yamashita S; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan. |
المصدر: | Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Aug; Vol. 12 (4), pp. e1249. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Hoboken, NJ] : John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics, [2013]- |
مواضيع طبية MeSH: | Captopril*/pharmacokinetics , Captopril*/administration & dosage , Captopril*/pharmacology , Nifedipine*/pharmacokinetics , Nifedipine*/administration & dosage , Nifedipine*/pharmacology , Rats, Inbred SHR* , Antihypertensive Agents*/pharmacokinetics , Antihypertensive Agents*/administration & dosage , Antihypertensive Agents*/pharmacology , Blood Pressure*/drug effects , Hypertension*/drug therapy , Hypertension*/chemically induced , Heart Rate*/drug effects, Animals ; Male ; Rats ; Drug Interactions ; Half-Life ; Drug Therapy, Combination |
مستخلص: | This study assessed the pharmacokinetics (PKs) and pharmacodynamics (PDs) of two antihypertensive drugs, nifedipine and captopril, by exploring their main (blood pressure [BP]) and secondary effects (heart rate [HR] and QT interval [QT]) in spontaneously hypertensive rats. This study aimed to assess the relationship between PKs and PDs. Using these PD parameters, BP, HR, and QT during coadministration were estimated. The coadministration of nifedipine and captopril resulted in an increase in nifedipine's total body clearance (CL (© 2024 The Author(s). Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: QT interval; blood pressure; captopril; heart rate; nifedipine; pharmacokinetic‐pharmacodynamic (PK‐PD) model; spontaneously hypertensive rat (SHR) |
المشرفين على المادة: | 9G64RSX1XD (Captopril) I9ZF7L6G2L (Nifedipine) 0 (Antihypertensive Agents) |
تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240719 |
رمز التحديث: | 20240719 |
مُعرف محوري في PubMed: | PMC11253705 |
DOI: | 10.1002/prp2.1249 |
PMID: | 39017590 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2052-1707 |
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DOI: | 10.1002/prp2.1249 |