دورية أكاديمية
Endometriosis Typology and Ovarian Cancer Risk.
| العنوان: | Endometriosis Typology and Ovarian Cancer Risk. |
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| المؤلفون: | Barnard ME; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Population Health Sciences, University of Utah, Salt Lake City.; Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts., Farland LV; Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, and Department of Obstetrics and Gynecology, College of Medicine-Tucson, University of Arizona, Tucson., Yan B; Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City., Wang J; Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City., Trabert B; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Population Health Sciences, University of Utah, Salt Lake City.; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City., Doherty JA; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Population Health Sciences, University of Utah, Salt Lake City., Meeks HD; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Pediatrics, University of Utah, Salt Lake City., Madsen M; Huntsman Cancer Institute, University of Utah, Salt Lake City., Guinto E; Huntsman Cancer Institute, University of Utah, Salt Lake City., Collin LJ; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Population Health Sciences, University of Utah, Salt Lake City., Maurer KA; Huntsman Cancer Institute, University of Utah, Salt Lake City.; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City.; Gynecologic Oncology, Intermountain Health, Salt Lake City, Utah., Page JM; Obstetrics & Gynecology, Intermountain Health, Salt Lake City, Utah., Kiser AC; Department of Biomedical Informatics, University of Utah, Salt Lake City., Varner MW; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City., Allen-Brady K; Department of Internal Medicine, University of Utah, Salt Lake City., Pollack AZ; George Mason University, Fairfax, Virginia., Peterson KR; Advanced Fertility Care, Scottsdale, Arizona., Peterson CM; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City., Schliep KC; Department of Family and Preventive Medicine, University of Utah Health, Salt Lake City. |
| المصدر: | JAMA [JAMA] 2024 Aug 13; Vol. 332 (6), pp. 482-489. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago : American Medical Association, 1960- |
| مواضيع طبية MeSH: | Endometriosis*/classification , Endometriosis*/epidemiology , Ovarian Neoplasms*/diagnosis , Ovarian Neoplasms*/epidemiology , Ovarian Neoplasms*/pathology, Adult ; Aged ; Female ; Humans ; Middle Aged ; Young Adult ; Cohort Studies ; Incidence ; Proportional Hazards Models ; Risk Factors ; Utah/epidemiology ; Retrospective Studies ; Ovary/pathology |
| مستخلص: | Importance: Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and ovarian cancer histotypes have not been well-described. Objective: To evaluate the associations of endometriosis subtypes with incidence of ovarian cancer, both overall and by histotype. Design, Setting, and Participants: Population-based cohort study using data from the Utah Population Database. The cohort was assembled by matching 78 893 women with endometriosis in a 1:5 ratio to women without endometriosis. Exposures: Endometriosis cases were identified via electronic health records and categorized as superficial endometriosis, ovarian endometriomas, deep infiltrating endometriosis, or other. Main Outcomes and Measures: Estimated adjusted hazard ratios (aHRs), adjusted risk differences (aRDs) per 10 000 women, and 95% CIs for overall ovarian cancer, type I ovarian cancer, and type II ovarian cancer comparing women with each type of endometriosis with women without endometriosis. Models accounted for sociodemographic factors, reproductive history, and past gynecologic operations. Results: In this Utah-based cohort, the mean (SD) age at first endometriosis diagnosis was 36 (10) years. There were 597 women with ovarian cancer. Ovarian cancer risk was higher among women with endometriosis compared with women without endometriosis (aHR, 4.20 [95% CI, 3.59-4.91]; aRD, 9.90 [95% CI, 7.22-12.57]), and risk of type I ovarian cancer was especially high (aHR, 7.48 [95% CI, 5.80-9.65]; aRD, 7.53 [95% CI, 5.46-9.61]). Ovarian cancer risk was highest in women with deep infiltrating endometriosis and/or ovarian endometriomas for all ovarian cancers (aHR, 9.66 [95% CI, 7.77-12.00]; aRD, 26.71 [95% CI, 20.01-33.41]), type I ovarian cancer (aHR, 18.96 [95% CI, 13.78-26.08]; aRD, 19.57 [95% CI, 13.80-25.35]), and type II ovarian cancer (aHR, 3.72 [95% CI, 2.31-5.98]; aRD, 2.42 [95% CI, -0.01 to 4.85]). Conclusions and Relevance: Ovarian cancer risk was markedly increased among women with ovarian endometriomas and/or deep infiltrating endometriosis. This population may benefit from counseling regarding ovarian cancer risk and prevention and could be an important population for targeted screening and prevention studies. |
| التعليقات: | Comment in: JAMA. 2024 Aug 13;332(6):460-461. doi: 10.1001/jama.2024.12357. (PMID: 39018063) |
| معلومات مُعتمدة: | R01 RR021746 United States RR NCRR NIH HHS; K00 CA212222 United States CA NCI NIH HHS; R01 HL164715 United States HL NHLBI NIH HHS; NU58DP007131 United States CC CDC HHS; K01 AG058781 United States AG NIA NIH HHS |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240813 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| مُعرف محوري في PubMed: | PMC11255975 |
| DOI: | 10.1001/jama.2024.9210 |
| PMID: | 39018030 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1538-3598 |
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| DOI: | 10.1001/jama.2024.9210 |