دورية أكاديمية
Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit.
| العنوان: | Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit. |
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| المؤلفون: | Zhong CC; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Xu Z; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Gan J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Yu YM; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Tang HM; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Zhu Y; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Yang JX; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Ding HL; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China haileimdar@yahoo.com caojl0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China., Cao JL; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou 221004, China haileimdar@yahoo.com caojl0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221004, China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, China.; Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Aug 21; Vol. 44 (34). Date of Electronic Publication: 2024 Aug 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Sevoflurane*/pharmacology , Anesthetics, Inhalation*/pharmacology , Nociception*/drug effects , Nociception*/physiology , Periaqueductal Gray*/drug effects , Periaqueductal Gray*/metabolism , Mice, Inbred C57BL*, Animals ; Male ; Mice ; Mesencephalon/drug effects ; Consciousness/drug effects ; Consciousness/physiology ; Anesthesia Recovery Period ; Capsaicin/pharmacology ; GABAergic Neurons/drug effects ; GABAergic Neurons/physiology |
| مستخلص: | Although anesthesia provides favorable conditions for surgical procedures, recent studies have revealed that the brain remains active in processing noxious signals even during anesthesia. However, whether and how these responses affect the anesthesia effect remains unclear. The ventrolateral periaqueductal gray (vlPAG), a crucial hub for pain regulation, also plays an essential role in controlling general anesthesia. Hence, it was hypothesized that the vlPAG may be involved in the regulation of general anesthesia by noxious stimuli. Here, we found that acute noxious stimuli, including capsaicin-induced inflammatory pain, acetic acid-induced visceral pain, and incision-induced surgical pain, significantly delayed recovery from sevoflurane anesthesia in male mice, whereas this effect was absent in the spared nerve injury-induced chronic pain. Pretreatment with peripheral analgesics could prevent the delayed recovery induced by acute nociception. Furthermore, we found that acute noxious stimuli, induced by the injection of capsaicin under sevoflurane anesthesia, increased c-Fos expression and activity in the GABAergic neurons of the ventrolateral periaqueductal gray. Specific reactivation of capsaicin-activated vlPAG GABA neurons mimicked the effect of capsaicin and its chemogenetic inhibition prevented the delayed recovery from anesthesia induced by capsaicin. Finally, we revealed that the vlPAG GABA neurons regulated the recovery from anesthesia through the inhibition of ventral tegmental area dopaminergic neuronal activity, thus decreasing dopamine (DA) release and activation of DA D Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.) |
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| فهرسة مساهمة: | Keywords: dopamine; nociception; recovery; sevoflurane anesthesia; ventral tegmental area; ventrolateral periaqueductal gray |
| المشرفين على المادة: | 38LVP0K73A (Sevoflurane) 0 (Anesthetics, Inhalation) S07O44R1ZM (Capsaicin) |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240821 Latest Revision: 20240824 |
| رمز التحديث: | 20240826 |
| مُعرف محوري في PubMed: | PMC11340287 |
| DOI: | 10.1523/JNEUROSCI.0740-24.2024 |
| PMID: | 39019613 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.0740-24.2024 |