دورية أكاديمية
Analysis of granulysin expression in vitiligo and halo-nevus.
| العنوان: | Analysis of granulysin expression in vitiligo and halo-nevus. |
|---|---|
| المؤلفون: | Hlača N; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000, Rijeka, Croatia., Vičić M; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000, Rijeka, Croatia. marijana.vicic@medri.uniri.hr., Kaštelan M; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000, Rijeka, Croatia., Dekanić A; Department of Pathology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000, Rijeka, Croatia., Prpić-Massari L; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000, Rijeka, Croatia. |
| المصدر: | Scientific reports [Sci Rep] 2024 Jul 17; Vol. 14 (1), pp. 16580. Date of Electronic Publication: 2024 Jul 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Vitiligo*/metabolism , Vitiligo*/pathology , Antigens, Differentiation, T-Lymphocyte*/metabolism , Nevus, Halo*/metabolism , Nevus, Halo*/pathology , Killer Cells, Natural*/metabolism , Killer Cells, Natural*/immunology, Humans ; Male ; Female ; Adult ; Middle Aged ; Skin/metabolism ; Skin/pathology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Melanocytes/metabolism ; Melanocytes/pathology ; Young Adult ; CD56 Antigen/metabolism ; Case-Control Studies |
| مستخلص: | Vitiligo and halo nevus are immune-mediated skin diseases that have a similar pathogenesis and involve cellular cytotoxicity mechanisms that are not yet fully understood. In this study, we investigated the expression patterns of the cytolytic molecule granulysin (GNLY) in different cytotoxic cells in skin samples of vitiligo and halo nevus. Skin biopsies were taken from perilesional and lesional skin of ten vitiligo patients, eight patients with halo nevus and ten healthy controls. We analysed the expression of GNLY by immunohistochemistry in CD8+ and CD56+ NK cells. A significantly higher accumulation of GNLY+, CD8+ GNLY+ and fewer CD56+ GNLY+ cells was found in the lesional skin of vitiligo and halo nevus than in the healthy skin. These cells were localised in the basal epidermis and papillary dermis, suggesting that GNLY may be involved in the immune response against melanocytes. Similarly, but to a lesser extent, upregulation of GNLY+ and CD8+ GNLY+ cells was observed in the perilesional skin of vitiligo and halo nevus compared to healthy controls. In this study, we demonstrated for the first time an increased expression of CD8+ GNLY+ T lymphocytes and CD56+ GNLY+ NK cells in lesions of vitiligo and halo nevus, indicating the role of GNLY in the pathogenesis of both diseases. (© 2024. The Author(s).) |
| References: | J Invest Dermatol. 2009 Sep;129(9):2220-32. (PMID: 19242513) Br J Dermatol. 2011 Apr;164(4):743-9. (PMID: 21114480) Nat Commun. 2019 May 16;10(1):2178. (PMID: 31097717) J Invest Dermatol. 2016 May;136(5):978-984. (PMID: 26827762) J Invest Dermatol. 2019 Oct;139(10):2174-2184.e4. (PMID: 30998983) Oxid Med Cell Longev. 2022 Jan 22;2022:8498472. (PMID: 35103096) Oncoimmunology. 2019 Jul 22;8(11):1641392. (PMID: 31646080) Immunol Lett. 2020 Jan;217:126-132. (PMID: 31726187) Pigment Cell Melanoma Res. 2021 Mar;34(2):236-243. (PMID: 33278065) Rev Assoc Med Bras (1992). 2024 May 20;70(5):e20231107. (PMID: 38775500) Front Immunol. 2021 Apr 14;12:613056. (PMID: 33936032) Dermatol Ther (Heidelb). 2020 Dec;10(6):1185-1198. (PMID: 32949337) Immunity. 2017 Feb 21;46(2):287-300. (PMID: 28214226) Acta Derm Venereol. 2019 Nov 1;99(12):1136-1142. (PMID: 31449312) Med Sci Monit. 2019 Feb 06;25:1017-1023. (PMID: 30723188) Br J Dermatol. 2000 Sep;143(3):573-81. (PMID: 10971331) Acta Derm Venereol. 2015 Jul;95(6):664-70. (PMID: 25721262) Diabetes Care. 2013 Sep;36(9):2794-802. (PMID: 23637351) J Dermatol Sci. 2017 Jul;87(1):50-59. (PMID: 28385330) Dermatology. 2020;236(6):571-592. (PMID: 32155629) J Invest Dermatol. 2018 Feb;138(2):355-364. (PMID: 28927891) J Dermatol Sci. 2014 Jan;73(1):74-9. (PMID: 24035442) Arch Dermatol. 2012 Apr;148(4):497-502. (PMID: 22508876) J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1089-1098. (PMID: 29341310) Case Rep Dermatol. 2013 Apr 05;5(1):93-8. (PMID: 23626547) Indian Dermatol Online J. 2024 Apr 29;15(3):431-436. (PMID: 38845658) Mol Med Rep. 2019 Oct;20(4):3617-3624. (PMID: 31485649) J Eur Acad Dermatol Venereol. 2008 Aug;22(8):970-6. (PMID: 18482314) Tissue Antigens. 2009 Mar;73(3):193-8. (PMID: 19254247) Biomedicines. 2022 Jul 08;10(7):. (PMID: 35884944) Free Radic Biol Med. 2019 Aug 1;139:80-91. (PMID: 31078730) Arch Dermatol Res. 2021 Aug;313(6):453-460. (PMID: 32785835) J Invest Dermatol. 2012 Jul;132(7):1869-76. (PMID: 22297636) J Inflamm Res. 2021 Aug 24;14:4111-4124. (PMID: 34466016) Curr Opin Immunol. 2019 Oct;60:19-29. (PMID: 31112765) Br J Dermatol. 2016 Jun;174(6):1318-26. (PMID: 26801009) Dermatol Res Pract. 2011;2011:750342. (PMID: 21747840) Chin Med J (Engl). 2017 Nov 20;130(22):2703-2708. (PMID: 29133759) J Neuroimmunol. 2008 May 30;196(1-2):159-65. (PMID: 18396337) Pigment Cell Melanoma Res. 2021 Mar;34(2):256-267. (PMID: 33346939) Lab Invest. 2003 May;83(5):683-95. (PMID: 12746478) Pigment Cell Melanoma Res. 2014 Mar;27(2):209-20. (PMID: 24354861) Acta Derm Venereol. 2021 Jul 13;101(7):adv00499. (PMID: 34219176) PLoS One. 2012;7(5):e37513. (PMID: 22649532) Nat Immunol. 2008 May;9(5):503-10. (PMID: 18425107) Front Immunol. 2023 May 23;14:1164124. (PMID: 37287971) |
| معلومات مُعتمدة: | bio-med-uniri-18-43 University of Rijeka Foundation; bio-med-uniri-18-43 University of Rijeka Foundation; bio-med-uniri-18-43 University of Rijeka Foundation; bio-med-uniri-18-43 University of Rijeka Foundation; bio-med-uniri-18-43 University of Rijeka Foundation |
| فهرسة مساهمة: | Keywords: CD8+ T cells; Granulysin; Halo-nevus; Melanocytes; Natural killer cells; Vitiligo |
| المشرفين على المادة: | 0 (GNLY protein, human) 0 (Antigens, Differentiation, T-Lymphocyte) 0 (CD56 Antigen) |
| تواريخ الأحداث: | Date Created: 20240717 Date Completed: 20240717 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| مُعرف محوري في PubMed: | PMC11254913 |
| DOI: | 10.1038/s41598-024-67494-9 |
| PMID: | 39020008 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-024-67494-9 |