دورية أكاديمية
Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
العنوان: | Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis. |
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المؤلفون: | Wang Z; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Tang P; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Xiao H; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Peng S; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Chen J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Wang Y; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Xu J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Yan Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Zhang J; Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, PR China.; College of Pharmacy, Chongqing Medical University, Chongqing, PR China., Deng J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Ma Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Zhu H; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Luo W; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Zhang D; Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA., Wang L; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Qin J; CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, PR China., Lan W; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Jiang J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China., Liu Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China. |
المصدر: | The Journal of pathology [J Pathol] 2024 Sep; Vol. 264 (1), pp. 68-79. Date of Electronic Publication: 2024 Jul 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Chichester : John Wiley And Sons Original Publication: London, Oliver & Boyd. |
مواضيع طبية MeSH: | Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/enzymology , Snail Family Transcription Factors*/metabolism , Snail Family Transcription Factors*/genetics , Epithelial-Mesenchymal Transition* , Transcription Factors*/metabolism , Transcription Factors*/genetics , E2F1 Transcription Factor*/metabolism , E2F1 Transcription Factor*/genetics , Histone Demethylases*/metabolism , Histone Demethylases*/genetics, Male ; Animals ; Humans ; Mice ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Mice, Knockout ; Signal Transduction ; Neoplasm Metastasis ; Mice, Transgenic ; Cell Movement |
مستخلص: | Metastasis is the primary culprit behind cancer-related fatalities in multiple cancer types, including prostate cancer. Despite great advances, the precise mechanisms underlying prostate cancer metastasis are far from complete. By using a transgenic mouse prostate cancer model (TRAMP) with and without Phf8 knockout, we have identified a crucial role of PHF8 in prostate cancer metastasis. By complexing with E2F1, PHF8 transcriptionally upregulates SNAI1 in a demethylation-dependent manner. The upregulated SNAI1 subsequently enhances epithelial-to-mesenchymal transition (EMT) and metastasis. Given the role of the abnormally activated PHF8/E2F1-SNAI1 axis in prostate cancer metastasis and poor prognosis, the levels of PHF8 or the activity of this axis could serve as biomarkers for prostate cancer metastasis. Moreover, targeting this axis could become a potential therapeutic strategy for prostate cancer treatment. © 2024 The Pathological Society of Great Britain and Ireland. (© 2024 The Pathological Society of Great Britain and Ireland.) |
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معلومات مُعتمدة: | 82372758 National Natural Science Foundation of China; 81802558 National Natural Science Foundation of China; 2018XLC1014 University Research Project of Army Medical University; 2019CXLCB006 University Research Project of Army Medical University; 2021XQN24 University Research Project of Army Medical University |
فهرسة مساهمة: | Keywords: E2F1; EMT; PHF8; SNAI1; metastasis; prostate cancer |
المشرفين على المادة: | 0 (Snail Family Transcription Factors) 0 (Transcription Factors) 0 (E2F1 Transcription Factor) 0 (SNAI1 protein, human) EC 1.14.11.- (PHF8 protein, human) EC 1.14.11.- (Histone Demethylases) 0 (E2F1 protein, human) 0 (Snai1 protein, mouse) 0 (E2f1 protein, mouse) |
تواريخ الأحداث: | Date Created: 20240718 Date Completed: 20240805 Latest Revision: 20240805 |
رمز التحديث: | 20240805 |
DOI: | 10.1002/path.6325 |
PMID: | 39022843 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-9896 |
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DOI: | 10.1002/path.6325 |