دورية أكاديمية
Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A Proof of Concept for NO 2 .
| العنوان: | Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A Proof of Concept for NO |
|---|---|
| المؤلفون: | Pallarés Porcar S; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Sánchez-Íñigo FJ; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Nuñez-Corcuera B; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Lozano Suárez J; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Arca-Lafuente S; Viral Hepatitis Reference and Research Laboratory. National Center of Microbiology, Institute of Health Carlos III (ISCIII). Madrid, Spain., Moyano Cárdaba C; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Fernandez Agudo A; Risk Assessment Unit. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII), Madrid, Spain., de Alba-Gonzalez M; Risk Assessment Unit. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Ramis R; Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Instituto de Salud Carlos III (ISCIII). Madrid, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., Galán-Madruga D; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., González-Caballero MDC; Risk Assessment Unit. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: mcgonzalez@isciii.es., Briz V; Viral Hepatitis Reference and Research Laboratory. National Center of Microbiology, Institute of Health Carlos III (ISCIII). Madrid, Spain., Guevara-Hernandez S; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., de Vega Pastor ME; Department of Air Quality. Urban Planning, Environment and Mobility Area. Madrid City Council., Sarigiannis D; Aristotle University of Thessaloniki, Department of Chemical Engineering, Environmental Engineering Laboratory, University Campus, Thessaloniki 54124, Greece; HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Balkan Center, Bldg. B, 10th km Thessaloniki-Thermi; University School of Advanced Study IUSS, Piazza della Vittoria 15, 27100 Pavia, Italy., Garcia Dos Santos S; Department of Atmospheric Pollution. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII). Madrid. Spain., Tarazona JV; Risk Assessment Unit. National Environmental Health Center (CNSA). Instituto de Salud Carlos III (ISCIII), Madrid, Spain. |
| المصدر: | Chemosphere [Chemosphere] 2024 Jul 16, pp. 142883. Date of Electronic Publication: 2024 Jul 16. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مستخلص: | Background: Regular monitoring of the air pollutant nitrogen dioxide (NO Objective: This study develops a new concept "Health Impact Pathways (HIPs)" using adversity as a probabilistic indicator of health effects. For this purpose, it integrates available toxicological and epidemiological information, using Adverse Outcome Pathways (AOPs), in order to understand chemical-biological interactions and their consequences on health. Methods: Literature review and meta-analysis of toxicological data supported by expert judgment were performed to establish: a) adversity pathways, b) quantitative criteria for scoring the observed toxicological effects (adversity indicators), c) NO Results: Non-linear relations were obtained for all long- and short-term NO Discussion: The proposed HIP conceptual approach offers promising advances for integrating experimental and epidemiological data. The next step is linking the concentration-adversity relationship with population health impacts through probability estimations, the preliminary estimations confirm the need for assessing independently different population groups. Competing Interests: Declaration of Competing Interest ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: (Copyright © 2024. Published by Elsevier Ltd.) |
| تواريخ الأحداث: | Date Created: 20240718 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1016/j.chemosphere.2024.142883 |
| PMID: | 39025310 |
| قاعدة البيانات: | MEDLINE |
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