دورية أكاديمية
أعرض في EDS

New arsenals for old armour: Biogenic nanoparticles in the battle against drug-resistant Candidaalbicans.

التفاصيل البيبلوغرافية
العنوان: New arsenals for old armour: Biogenic nanoparticles in the battle against drug-resistant Candidaalbicans.
المؤلفون: Padmavathi AR; Biofouling and Biofilm Processes Section, Water and Steam Chemistry Division, Bhabha Atomic Research Centre, Kalpakkam, 603 102, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India. Electronic address: padma@igcar.gov.in., Reddy GKK; Biofouling and Biofilm Processes Section, Water and Steam Chemistry Division, Bhabha Atomic Research Centre, Kalpakkam, 603 102, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India., Murthy PS; Biofouling and Biofilm Processes Section, Water and Steam Chemistry Division, Bhabha Atomic Research Centre, Kalpakkam, 603 102, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India., Nancharaiah YV; Biofouling and Biofilm Processes Section, Water and Steam Chemistry Division, Bhabha Atomic Research Centre, Kalpakkam, 603 102, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India.
المصدر: Microbial pathogenesis [Microb Pathog] 2024 Sep; Vol. 194, pp. 106800. Date of Electronic Publication: 2024 Jul 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London ; Orlando : Academic Press, c1986-
مواضيع طبية MeSH: Antifungal Agents*/pharmacology , Biofilms*/drug effects , Drug Resistance, Fungal*/drug effects , Metal Nanoparticles*/chemistry , Candida albicans*/drug effects, Humans ; Microbial Sensitivity Tests ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Nanoparticles/chemistry
مستخلص: Candida albicans is a common commensal fungus and fourth most frequent causative agent of nosocomial infections including life-threatening invasive candidiasis in humans. The effectiveness of present antifungal therapies using azoles, polyenes, flucytosine and echinocandins has plateaued in managing fungal infections. The limitations of these antifungal drugs are related to polymorphic morphology, biofilm formation, emergence of drug-resistant strains and production of several virulence factors. Development of new antifungal agents, which can particularly afflict multiple cellular targets and limiting evolving resistant strains are needed. Recently, metal nanoparticles have emerged as a source of new antifungal agents for antifungal formulations. Furthermore, green nanotechnology deals with the use of biosynthetic routes that offer new avenue for synthesizing antifungal nanoparticles coupled with less toxic chemical inventory and environmental sustainability. This article reviews the recent developments on C. albicans pathogenesis, biofilm formation, drug resistance, mode of action of antifungal drugs and antifungal activities of metal nanoparticles. The antifungal efficacy and mode of action of metal nanoparticles are described in the context of prospective therapeutic applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Antifungal nanoparticles; Antimicrobial resistance; Biofilm; Candida albicans; Green synthesis; Virulence
المشرفين على المادة: 0 (Antifungal Agents)
تواريخ الأحداث: Date Created: 20240718 Date Completed: 20240831 Latest Revision: 20240831
رمز التحديث: 20240902
DOI: 10.1016/j.micpath.2024.106800
PMID: 39025380
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-1208
DOI:10.1016/j.micpath.2024.106800