دورية أكاديمية
Pharmacokinetics of a topical application of moxidectin in bare-nosed wombats (Vombatus ursinus).
| العنوان: | Pharmacokinetics of a topical application of moxidectin in bare-nosed wombats (Vombatus ursinus). |
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| المؤلفون: | Stannard HJ; School of Agricultural, Environmental and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia. Electronic address: hstannard@csu.edu.au., Wynan MB; Jarake Wildlife Sanctuary Ltd, Nimmitabel, NSW, Australia; Wombat Protection Society of Australia, Tomerong, NSW, Australia., Wynan RJ; Jarake Wildlife Sanctuary Ltd, Nimmitabel, NSW, Australia., Cox A; Wombat Protection Society of Australia, Tomerong, NSW, Australia., Ralph H; Southern Cross Wildlife Care, Braidwood, NSW, Australia., Doran GS; School of Agricultural, Environmental and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia; Gulbali Institute, Charles Sturt University, Albert Pugsley Place, Wagga Wagga, NSW, Australia. |
| المصدر: | Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2024 Aug; Vol. 53, pp. 101074. Date of Electronic Publication: 2024 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101680410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-9390 (Electronic) Linking ISSN: 24059390 NLM ISO Abbreviation: Vet Parasitol Reg Stud Reports Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, [2015]- |
| مواضيع طبية MeSH: | Macrolides*/pharmacokinetics , Macrolides*/administration & dosage , Administration, Topical* , Scabies*/drug therapy , Scabies*/veterinary , Marsupialia*, Animals ; Half-Life ; Female ; Male |
| مستخلص: | Sarcoptic mange is a debilitating disease that affects bare-nosed wombats (Vombatus ursinus). One of the drugs currently used for treatment is moxidectin, as it has a relatively high efficacy against endo and ectoparasites and side effects are uncommon in domestic species, thus it is considered a relatively safe drug to use at the recommended doses. Developing further understanding of the pharmacokinetics of moxidectin will aid in developing treatment regimens for sarcoptic mange in wombats. Here we analyzed the pharmacokinetic parameters of using 100 ml of moxidectin (5 g/l) applied topically. We found that mean peak plasma concentration was 0.50 ng/ml and half-life was 8 days. Moxidectin was excreted in scats with the mean peak concentration of 2461.43 ng/g (on a dry matter basis). Our study has provided the pharmacokinetic parameters of a commonly used treatment for sarcoptic mange in wombats. There were no adverse side effects recorded in the wombats after applying moxidectin topically. This study replicated real-world conditions using topical application on free-living wombats. The relatively low plasma concentration suggests the drug is not accumulating in the blood stream and is excreted via scats. Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hayley Stannard reports financial support was provided by Wombat Protection Society of Australia. Marie Wynan reports a relationship with Wombat Protection Society of Australia that includes: board membership. Amanda Cox reports a relationship with Wombat Protection Society of Australia that includes: board membership. The other authors, declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood; Cydectin®; Plasma; Sarcoptes scabiei; Sarcoptic mange; Scat |
| المشرفين على المادة: | NGU5H31YO9 (moxidectin) 0 (Macrolides) |
| SCR Organism: | Vombatus ursinus |
| تواريخ الأحداث: | Date Created: 20240718 Date Completed: 20240718 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1016/j.vprsr.2024.101074 |
| PMID: | 39025544 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2405-9390 |
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| DOI: | 10.1016/j.vprsr.2024.101074 |