دورية أكاديمية
Patient-Reported Outcome Screens for Cognitive Dysfunction and Predicts Admissions in Cirrhosis.
| العنوان: | Patient-Reported Outcome Screens for Cognitive Dysfunction and Predicts Admissions in Cirrhosis. |
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| المؤلفون: | Thuluvath AJ; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medicine, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Northwestern University, Chicago, Illinois, USA. Electronic address: avesh.j.thuluvath@gmail.com., Kim M; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Neurology, Feinberg School of Medicine, Division of Stroke and Neurocritical Care, Northwestern University, Chicago, Illinois, USA., Peipert J; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Duarte-Rojo A; Division of Gastroenterology and Hepatology, Starzl Transplantation Institute and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Huang A; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Siddiqui O; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Nizamuddin M; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Dietch Z; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Division of Transplant, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Levitsky J; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medicine, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Northwestern University, Chicago, Illinois, USA., Ladner DP; Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Division of Transplant, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. |
| المصدر: | Transplantation proceedings [Transplant Proc] 2024 Jul-Aug; Vol. 56 (6), pp. 1378-1384. Date of Electronic Publication: 2024 Jul 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, N.Y. : Elsevier Science Inc. Original Publication: New York Stratton. |
| مواضيع طبية MeSH: | Liver Cirrhosis*/complications , Liver Cirrhosis*/surgery , Patient Reported Outcome Measures* , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/epidemiology , Hepatic Encephalopathy*/etiology , Hepatic Encephalopathy*/diagnosis , Hepatic Encephalopathy*/epidemiology, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Liver Transplantation ; Aged ; Hospitalization ; Neuropsychological Tests ; Cognition |
| مستخلص: | Introduction: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis, leading to preventable hospitalizations and increased mortality. Despite the availability of validated neuro-psychometric tests to diagnose HE, only 10% of clinicians regularly screen for HE due to lack of time, equipment, and trained personnel. Materials and Methods: We studied the association between patient-reported cognitive function and the National Institutes of Health Toolbox Cognition Battery (a validated measure of HE) in patients with cirrhosis. A single-center prospective study of adult patients undergoing liver transplantation evaluation was performed from 10/2020 to 12/2021. Cognition was assessed using the National Institutes of Health Toolbox Cognition Battery and a brief Patient-Reported Outcomes Measurement Information System (PROMIS) survey. Results: Twenty-three liver transplantation candidates were enrolled; the mean age was 56.4 (±9.7) years, 39% were female and the most common etiologies of cirrhosis were primary biliary cirrhosis/primary sclerosing cholangitis/overlap syndrome (30%), hepatitis C (22%) and alcohol-associated liver disease (22%). The mean MELD-Na was 14.9 (±6.4). The mean PROMIS Cognitive Function T-score (PROMIS Conclusions: A brief survey can screen for HE and predict hospitalizations in patients with cirrhosis. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240718 Date Completed: 20240829 Latest Revision: 20240829 |
| رمز التحديث: | 20240831 |
| DOI: | 10.1016/j.transproceed.2024.03.039 |
| PMID: | 39025730 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2623 |
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| DOI: | 10.1016/j.transproceed.2024.03.039 |