دورية أكاديمية
Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet.
| العنوان: | Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet. |
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| المؤلفون: | Yonemoto E; D ivision of Food Science and Biotechnology, Graduated School of Science and Technology, Shinshu University, Kamiina, Nagano, Japan., Ihara R; Department of Agricultural and Life Sciences, Faculty of Agriculture, Shinshu University, Kamiina, Nagano, Japan., Tanaka E; D ivision of Food Science and Biotechnology, Graduated School of Science and Technology, Shinshu University, Kamiina, Nagano, Japan., Mitani T; D ivision of Food Science and Biotechnology, Graduated School of Science and Technology, Shinshu University, Kamiina, Nagano, Japan.; Department of Agricultural and Life Sciences, Faculty of Agriculture, Shinshu University, Kamiina, Nagano, Japan. |
| المصدر: | Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2024 Sep 20; Vol. 88 (10), pp. 1188-1198. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9205717 Publication Model: Print Cited Medium: Internet ISSN: 1347-6947 (Electronic) Linking ISSN: 09168451 NLM ISO Abbreviation: Biosci Biotechnol Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Oxford : Oxford University Press Original Publication: Tokyo, Japan : Japan Society for Bioscience, Biotechnology, and Agrochemistry, c1992- |
| مواضيع طبية MeSH: | Diet, High-Fat*/adverse effects , Glucose Intolerance*/drug therapy , Glucose Intolerance*/metabolism , Cacao*/chemistry , Plant Extracts*/pharmacology , Uncoupling Protein 1*/metabolism , Uncoupling Protein 1*/genetics , Adipocytes, White*/drug effects , Adipocytes, White*/metabolism , Mice, Inbred C57BL*, Animals ; Mice ; Male ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Receptors, Adrenergic, beta-3/metabolism ; Receptors, Adrenergic, beta-3/genetics ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, Brown/metabolism ; Adipocytes, Brown/drug effects ; Adipocytes, Brown/metabolism |
| مستخلص: | Cocoa extract (CE) offers several health benefits, such as antiobesity and improved glucose intolerance. However, the mechanisms remain unclear. Adipose tissue includes white adipose tissue (WAT) and brown adipose tissue. Brown adipose tissue leads to body fat reduction by metabolizing lipids to heat via uncoupling protein 1 (UCP1). The conversion of white adipocytes into brown-like adipocytes (beige adipocytes) is called browning, and it contributes to the anti-obesity effect and improved glucose tolerance. This study aimed to evaluate the effect of CE on glucose tolerance in terms of browning. We found that dietary supplementation with CE improved glucose intolerance in mice fed a high-fat diet, and it increased the expression levels of Ucp1 and browning-associated gene in inguinal WAT. Furthermore, in primary adipocytes of mice, CE induced Ucp1 expression through β3-adrenergic receptor stimulation. These results suggest that dietary CE improves glucose intolerance by inducing browning in WAT. (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.) |
| معلومات مُعتمدة: | 23K05109 Japan Society for the Promotion of Science |
| فهرسة مساهمة: | Keywords: beige adipocyte; cocoa; glucose intolerance; uncoupling protein 1; β3-adrenergic receptor |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Uncoupling Protein 1) 0 (Ucp1 protein, mouse) 0 (Receptors, Adrenergic, beta-3) |
| تواريخ الأحداث: | Date Created: 20240718 Date Completed: 20240920 Latest Revision: 20240920 |
| رمز التحديث: | 20240921 |
| DOI: | 10.1093/bbb/zbae105 |
| PMID: | 39025807 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-6947 |
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| DOI: | 10.1093/bbb/zbae105 |