دورية أكاديمية
Aspergillus Endophthalmitis Secondary to Infectious Scleritis: Utility of Diagnostic PCR.
| العنوان: | Aspergillus Endophthalmitis Secondary to Infectious Scleritis: Utility of Diagnostic PCR. |
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| المؤلفون: | Elwood KF; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison., Warner EJ, Chang JS, Kopplin LJ |
| المصدر: | Retinal cases & brief reports [Retin Cases Brief Rep] 2024 Jul 19. Date of Electronic Publication: 2024 Jul 19. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101298744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-1578 (Electronic) Linking ISSN: 19351089 NLM ISO Abbreviation: Retin Cases Brief Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Wolters Kluwer Health, c2007- |
| مستخلص: | Purpose: To describe a case of delayed-onset Aspergillus fumigatus endophthalmitis secondary to infectious fungal scleritis diagnosed with broad range polymerase chain reaction (PCR) from scleral nodular debridement and vitreous sampling during vitrectomy. Methods: Retrospective case report with slit lamp photography, optical coherence tomography, and fundus photography. Results: A 76-year-old man presented with right eye worsening vision and pain concerning for progressive nodular scleritis and endophthalmitis eight months following a reportedly innocuous tree branch injury. Following the injury, he underwent an MRI, surgical exploration, subconjunctival antibiotic administration, and culturing due to persistent foreign body sensation. Cultures were negative, and the patient was started on oral NSAIDs, oral prednisone, and periocular triamcinolone injections following negative/normal infectious and rheumatologic workup for scleritis. The patient was referred for worsened scleritis with development of endophthalmitis. He underwent lamellar sclerectomy, debridement, and culture of purulent material from scleral nodules in coordination with diagnostic vitrectomy, vitreous sampling, and subconjunctival and intravitreal antibiotic and antifungal treatment. Broad range PCR was positive for Aspergillus fumigatus and targeted antifungal treatment initiated. The eye did not regain visual function and was enucleated for progressive pain six months following diagnosis. Conclusion: Fungal scleritis and endophthalmitis results in significant morbidity. Diagnostic vitrectomy and broad range PCR can aid in prompt diagnosis and targeted treatment, and may be useful in refractory cases. |
| تواريخ الأحداث: | Date Created: 20240719 Latest Revision: 20240719 |
| رمز التحديث: | 20240720 |
| DOI: | 10.1097/ICB.0000000000001633 |
| PMID: | 39029105 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-1578 |
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| DOI: | 10.1097/ICB.0000000000001633 |