دورية أكاديمية
Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells.
| العنوان: | Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells. |
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| المؤلفون: | Li F; School hospital, Shandong University of Science and Technology, No.579, Qianwangang Road, Qingdao 266590, People's Republic of China., Zhang L; School hospital, Shandong University of Science and Technology, No.579, Qianwangang Road, Qingdao 266590, People's Republic of China., Zhang X; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Ji'nan 250062, People's Republic of China., Fang Q; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Ji'nan 250062, People's Republic of China., Xu Y; School hospital, Shandong University of Science and Technology, No.579, Qianwangang Road, Qingdao 266590, People's Republic of China., Wang H; Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Ji'nan 250062, People's Republic of China. Electronic address: wanghui565833948@126.com. |
| المصدر: | Neurotoxicology [Neurotoxicology] 2024 Sep; Vol. 104, pp. 1-10. Date of Electronic Publication: 2024 Jul 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : Amsterdam : Elsevier Science Original Publication: Park Forest South, Ill., Pathotox Publishers. |
| مواضيع طبية MeSH: | NF-E2-Related Factor 2*/metabolism , Oxidative Stress*/drug effects , Rutin*/pharmacology , Cell Death*/drug effects , Lead*/toxicity , Antioxidant Response Elements*/drug effects, Humans ; Cell Line, Tumor ; Inflammation/metabolism ; Inflammation/chemically induced ; Neuroprotective Agents/pharmacology ; Cell Survival/drug effects ; Antioxidants/pharmacology |
| مستخلص: | Lead (Pb) is harmful to almost all organs, particularly the developmental neural system, and previous studies revealed oxidative stress played an important role in Pb neurotoxicity. Rutin, a type of flavonoid glycoside found in various plants and fruits, is widely used as a dietary supplement due to its antioxidant and anti-inflammatory properties, but whether rutin could protect against Pb neurotoxicity is unclear. In this study, we found rutin treatment significantly alleviated Pb-induced cell death, oxidative stress, and inflammation, resulting in cell survival. Moreover, rutin treatment promoted nuclear factor erythroid 2-related factor 2 (Nrf2) translocation from cytoplasm to nucleus and subsequently activated antioxidant and detoxifying enzymes expression including HO-1. Knocking down Nrf2 by siRNA transfection abolished this protection of rutin against Pb. Overall, rutin could alleviate Pb-induced oxidative stress, inflammation, and cell death by activating the Nrf2/antioxidant response elements (ARE) system. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Inflammation; Lead; Nrf2; Oxidative stress; Rutin |
| المشرفين على المادة: | 0 (NF-E2-Related Factor 2) 5G06TVY3R7 (Rutin) 0 (NFE2L2 protein, human) 2P299V784P (Lead) 0 (Neuroprotective Agents) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20240720 Date Completed: 20240905 Latest Revision: 20240905 |
| رمز التحديث: | 20240906 |
| DOI: | 10.1016/j.neuro.2024.07.010 |
| PMID: | 39032614 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-9711 |
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| DOI: | 10.1016/j.neuro.2024.07.010 |