دورية أكاديمية
Cardiovascular events after invasive pneumococcal disease: a retrospective cohort study.
| العنوان: | Cardiovascular events after invasive pneumococcal disease: a retrospective cohort study. |
|---|---|
| المؤلفون: | Dulfer EA; Department of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Centre, 6525 GA Nijmegen, the Netherlands; Department of Internal Medicine, Maasziekenhuis Pantein, 5835 DV Beugen, the Netherlands. Electronic address: elisabeth.dulfer@raboudumc.nl., Serbée MJV; Department of Clinical Microbiology and Immunology, Rijnstate, 6815 AD Arnhem, the Netherlands., Dirkx KKT; Department of Clinical Microbiology, Canisius-Wilhelmina Ziekenhuis, 6532 SZ Nijmegen, the Netherlands., Schaars CF; Department of Internal Medicine, Maasziekenhuis Pantein, 5835 DV Beugen, the Netherlands., Wertheim HFL; Department of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Centre, 6525 GA Nijmegen, the Netherlands., de Jonge MI; Laboratory of Medical Immunology, Radboud Centre for Infectious Diseases, Radboud University Medical Centre, 6525 GA Nijmegen, the Netherlands., Cremers AJH; Department of Clinical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Centre, 6525 GA Nijmegen, the Netherlands; Department of Clinical Microbiology and Immunology, Rijnstate, 6815 AD Arnhem, the Netherlands. |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jul 19; Vol. 147, pp. 107185. Date of Electronic Publication: 2024 Jul 19. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مستخلص: | Objectives: This study aims to understand the magnitude of and mechanisms underlying the development of cardiovascular events (CVEs) in patients with invasive pneumococcal disease (IPD). We aimed to identify factors that contribute to the occurrence of CVEs within 1 year after admission and discuss implications for patient care. Methods: A multicentered cohort study included adult patients from four Dutch hospitals who had a positive blood culture for Streptococcus pneumoniae and any type of clinical manifestation between 2012 and 2020. Disease characteristics and microbiological data were systematically collected from electronic patient files. The main outcome measures were the occurrence of stroke and acute coronary syndromes (ACS). Results: Of 914 eligible patients, 4.2% experienced a CVE within 1 year after admission for IPD. ACS mainly occurred in the first 2 weeks, whereas stroke developed throughout follow-up. Although ACS was positively associated with disease severity, the sole independent predictor was alcohol abuse (odds ratio [OR] 3.840, 95% confidence interval [CI] 1.108-13.303). Although stroke occurred in 6.3% of meningitis cases, the best clinical predictor of stroke was a body temperature >39.5 °C at admission (OR 3.117 [1.154-8.423]). In the adult IPD population aged <70 years, pneumococcal serotypes were the primary predictors of ACS (7F; OR 15.733 [1.812-136.632]) and stroke (22F; OR 7.320 [1.193-44.903]). Conclusions: Adverse CVEs were not uncommon after IPD diagnosis and deserve attention, especially in the high-risk groups we identified in our study population. Whether specific serotypes play a role in the development of CVE requires substantiation in further research. Competing Interests: Declarations of competing interest The authors have no competing interests to declare. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acute coronary syndrome; Cardiovascular event; Invasive pneumococcal disease; Streptococcus pneumoniae; Stroke |
| تواريخ الأحداث: | Date Created: 20240721 Latest Revision: 20240810 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1016/j.ijid.2024.107185 |
| PMID: | 39033798 |
| قاعدة البيانات: | MEDLINE |
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