دورية أكاديمية
Histone deacetylase 8 promotes innate antiviral immunity through deacetylation of RIG-I.
| العنوان: | Histone deacetylase 8 promotes innate antiviral immunity through deacetylation of RIG-I. |
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| المؤلفون: | Zhang H; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China.; School of Basic Medical and Forensic Medicine, Henan University of Science & Technology, Luoyang, China., Liu T; Department of Medical Laboratory, Fenyang College of Shanxi Medical University, Fenyang, China., Liu X; Pharmacy Department, Luohe Hosptial Of Traditional Chinese Medicine, Luohe, China., You F; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China., Yang J; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China., Zhang N; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China., Huang Y; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China., Liang G; Institute of Biomedical Research, Henan Academy Of Sciences, Zhengzhou, China.; School of Basic Medical and Forensic Medicine, Henan University of Science & Technology, Luoyang, China. |
| المصدر: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Jul 05; Vol. 14, pp. 1415695. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA |
| مواضيع طبية MeSH: | DEAD Box Protein 58*/metabolism , DEAD Box Protein 58*/genetics , Immunity, Innate* , Histone Deacetylases*/metabolism , Virus Replication* , Vesiculovirus*/immunology , Signal Transduction* , Receptors, Immunologic*/metabolism, Humans ; Repressor Proteins/metabolism ; Repressor Proteins/genetics ; Acetylation ; HEK293 Cells ; Interferons/metabolism ; Interferons/immunology ; Cell Line ; Host-Pathogen Interactions/immunology ; Animals ; Vesicular stomatitis Indiana virus/immunology |
| مستخلص: | Histone deacetylates family proteins have been studied for their function in regulating viral replication by deacetylating non-histone proteins. RIG-I (Retinoic acid-inducible gene I) is a critical protein in RNA virus-induced innate antiviral signaling pathways. Our previous research showed that HDAC8 (histone deacetylase 8) involved in innate antiviral immune response, but the underlying mechanism during virus infection is still unclear. In this study, we showed that HDAC8 was involved in the regulation of vesicular stomatitis virus (VSV) replication. Over-expression of HDAC8 inhibited while knockdown promoted VSV replication. Further exploration demonstrated that HDAC8 interacted with and deacetylated RIG-I, which eventually lead to enhance innate antiviral immune response. Collectively, our data clearly demonstrated that HDAC8 inhibited VSV replication by promoting RIG-I mediated interferon production and downstream signaling pathway. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Zhang, Liu, Liu, You, Yang, Zhang, Huang and Liang.) |
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| فهرسة مساهمة: | Keywords: HDAC8; VSV; antiviral; innate immunity; molecular mechanism |
| المشرفين على المادة: | EC 3.6.4.13 (DEAD Box Protein 58) EC 3.5.1.98 (Histone Deacetylases) EC 3.6.1.- (RIGI protein, human) 0 (Receptors, Immunologic) EC 3.5.1.98 (HDAC8 protein, human) 0 (Repressor Proteins) 9008-11-1 (Interferons) |
| تواريخ الأحداث: | Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240723 |
| رمز التحديث: | 20240723 |
| مُعرف محوري في PubMed: | PMC11257846 |
| DOI: | 10.3389/fcimb.2024.1415695 |
| PMID: | 39035358 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2024.1415695 |