دورية أكاديمية
أعرض في EDS

Evaluation of the remineralization potential of self-assembling peptide P11-4 with fluoride compared to fluoride varnish in the management of incipient carious lesions: a randomized controlled clinical trial.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the remineralization potential of self-assembling peptide P11-4 with fluoride compared to fluoride varnish in the management of incipient carious lesions: a randomized controlled clinical trial.
المؤلفون: Shaalan O; Conservative Dentistry Department, Faculty of Dentistry, Cairo University, Al Saraya Str. 11, Manial, Cairo, Egypt.; Conservative Dentistry Division, School of Dentistry, Newgiza University, First 6th of October, Egypt., Fawzy El-Sayed K; Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Giza, Egypt.; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany., Abouauf E; Conservative Dentistry Department, Faculty of Dentistry, Cairo University, Al Saraya Str. 11, Manial, Cairo, Egypt. e.abouauf@dentistry.cu.edu.eg.
المصدر: Clinical oral investigations [Clin Oral Investig] 2024 Jul 22; Vol. 28 (8), pp. 438. Date of Electronic Publication: 2024 Jul 22.
نوع المنشور: Journal Article; Randomized Controlled Trial; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
مواضيع طبية MeSH: Dental Caries* , Tooth Remineralization*/methods , Fluorides, Topical*/therapeutic use , Sodium Fluoride*/therapeutic use , Cariostatic Agents*/therapeutic use, Humans ; Female ; Male ; Adult ; Treatment Outcome ; Middle Aged ; Oligopeptides
مستخلص: Objectives: The present trial's aim was to compare the remineralization potential of self-assembling peptide P11-4 combined with fluoride to that of fluoride varnish.
Materials and Methods: Twenty-eight participants with 58 incipient carious lesions were enrolled in the present trial. Participants were randomly divided into two groups with 14 participants and 29 incipient lesions in each group. Patients were assigned either to self-assembling peptide combined with fluoride (Curodont Repair Fluoride Plus™) or sodium fluoride varnish (NaF, Bifluorid 10) groups. Both agents were applied according to the manufacturer's instructions on non-cavitated incipient carious lesions. Lesions were assessed by two calibrated and blinded assessors at baseline, and after one-, three- and six-months using a laser fluorescence device (DIAGNOdent).
Results: Although laser fluorescence scores significantly improved in both groups over time (p < 0.05), no notable differences were evident between both groups at one-month (p > 0.05). Yet, at three- and six-months statistically lower laser fluorescence readings were evident in the self-assembling peptide combined with fluoride group in comparison to the fluoride alone group (p < 0.05). There was 60% less risk for caries progression for Curodont Repair Fluoride Plus™ when compared to NaF varnish after six months. Self-assembling peptide combined with fluoride was able to change 65.5% of non-cavitated carious lesions from DIAGNOdent score 3 (11-20) to score 1 (0-4). Fluoride varnish was able to change 13.8% of the lesions from score 3 to score 1 after six months.
Conclusions: The self-assembling peptide combined with fluoride varnish showed higher remineralization potential than fluoride varnish alone for incipient carious lesions over a six-months follow up.
Clinical Relevance: The combination of self-assembling peptide P11-4 and fluoride could offer a new tool in managing incipient carious lesions.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Caries; Enamel; Fluorescence; Fluoride; Incipient; Laser; Non-cavitated; P11-4; Remineralization; Self-assembling peptide; Varnish
المشرفين على المادة: 0 (Fluorides, Topical)
0 (P11-4 peptide)
8ZYQ1474W7 (Sodium Fluoride)
0 (Cariostatic Agents)
0 (sodium fluoride topical preparation)
0 (Oligopeptides)
تواريخ الأحداث: Date Created: 20240722 Date Completed: 20240722 Latest Revision: 20240823
رمز التحديث: 20240823
مُعرف محوري في PubMed: PMC11263456
DOI: 10.1007/s00784-024-05822-z
PMID: 39037455
قاعدة البيانات: MEDLINE
الوصف
تدمد:1436-3771
DOI:10.1007/s00784-024-05822-z