دورية أكاديمية
Transient elastography for significant fibrosis in treatment-naïve CHB patients: A systematic review and meta-analysis.
| العنوان: | Transient elastography for significant fibrosis in treatment-naïve CHB patients: A systematic review and meta-analysis. |
|---|---|
| المؤلفون: | Kim MN; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea., An J; Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea., Kim EH; Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim HY; Department of Internal Medicine, College of Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea., Lee HA; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea., Yu JH; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., Jin YJ; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., Chon YE; Department of Internal Medicine, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Kim SU; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea., Jun DW; Department of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea., Han JW; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea., Choi M; Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul, Republic of Korea. |
| المصدر: | Clinical and molecular hepatology [Clin Mol Hepatol] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Korea : Korean Association for the Study of the Liver |
| مستخلص: | Background and Aims: Accurate diagnosis of significant liver fibrosis in patients with chronic hepatitis B (CHB) is crucial when determining whether to initiate antiviral treatment (AVT). We conduct a meta-analysis to assess the diagnostic performance of transient elastography (TE) for significant liver fibrosis in AVT-naïve CHB patients with serum alanine transaminase (ALT) levels within 5-fold the upper limit of normal (ULN). Methods: The Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched to identify studies that compared the performance of TE and liver biopsy (reference standard) when diagnosing significant liver fibrosis (≥ F2) in AVT-naïve CHB patients with ALT within 5-fold the ULN. A hierarchical summary receiver operating characteristic curve (HSROC) and bivariate model were performed to evaluate the diagnostic performance of TE in the meta-analysis. Results: Eight studies (2,003 patients) were included. The summary sensitivity and specificity for diagnosis of significant liver fibrosis were 0.78 [95% confidence interval (CI), 0.66-0.86] and 0.72 (95% CI, 0.60-0.82), respectively. The HSROC for the diagnosis of significant liver fibrosis was 0.81 (95% CI, 0.72-0.86). The optimal cut-off value of TE for diagnosis of significant liver fibrosis was 7.7 kPa with a sensitivity of 0.64 (95% CI, 0.50-0.76) and specificity of 0.83 (95% CI, 0.72-0.90). Conclusions: Our study demonstrated that TE has an acceptable diagnostic performance for significant liver fibrosis in AVT-naïve CHB patients with ALT within 5-fold the ULN. |
| فهرسة مساهمة: | Keywords: Significant liver fibrosis; Transient elastography; antiviral treatment-naïve; Chronic hepatitis B |
| تواريخ الأحداث: | Date Created: 20240723 Latest Revision: 20240731 |
| رمز التحديث: | 20240731 |
| DOI: | 10.3350/cmh.2024.0371 |
| PMID: | 39043361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2287-285X |
|---|---|
| DOI: | 10.3350/cmh.2024.0371 |