دورية أكاديمية
Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective.
| العنوان: | Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective. |
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| المؤلفون: | El-Kerdasy HI; Department of Anatomy and Embryology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Faruk EM; Anatomy Department, College of Medicine, Umm Al-Qura University, 24230, Makkah, Saudi Arabia.; Department of Histology and Cell Biology, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Hassan DAA; Department of Histology and Cell Biology, Faculty of Medicine for Girls (AFMG), Al-Azhar University, Nasr CityCairo, 11884, Egypt., Nafea OE; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt. olanafea@zu.edu.eg., Ibrahim F; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt., Bagabir RA; Hematology and Immunology Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Anwer HM; Physiology Department, Faculty of Medicine, Benha University, Benha, 13518, Egypt., Allam AM; Department of Anatomy and Embryology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.; Department of Anatomy, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, P.O. Box 330127, Zarqa, 13133, Jordan. |
| المصدر: | Inflammopharmacology [Inflammopharmacology] 2024 Oct; Vol. 32 (5), pp. 3475-3498. Date of Electronic Publication: 2024 Jul 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel ; Boston : Birkhäuser Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- |
| مواضيع طبية MeSH: | Stomach Ulcer*/drug therapy , Stomach Ulcer*/chemically induced , Ethanol* , Rosuvastatin Calcium*/pharmacology, Animals ; Male ; Rats ; Antioxidants/pharmacology ; Drug Repositioning ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Anti-Ulcer Agents/pharmacology ; Anti-Ulcer Agents/administration & dosage ; Dinoprostone/metabolism ; Peroxidase/metabolism ; Dose-Response Relationship, Drug ; Rats, Wistar ; Disease Models, Animal |
| مستخلص: | Ethanol (EtOH) consumption is frequently associated with acute and chronic gastrointestinal disorders. Rosuvastatin (RSV), a third-generation statin, has demonstrated certain biological functions beyond its lipid-lowering properties. This study is designed to explore the gastroprotective impact of RSV in a rat model of EtOH-induced gastric ulceration in a dose-dependent manner through the evaluation of oxidant/antioxidant biomarkers, inflammatory myeloperoxidase (MPO) enzyme activity, and prostaglandin E2 (PGE (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| References: | Abdeen A, Aboubakr M, Elgazzar D, Abdo M, Abdelkader A, Ibrahim S, Elkomy A (2019) Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats. Biomed Pharmacother 110:895–905. https://doi.org/10.1016/j.biopha.2018.11.004. (PMID: 10.1016/j.biopha.2018.11.00430572194) Abdullah DA, Almukhtar H (2023) Statin gastroprotective mechanisms independent of gastric acid suppression. Iraqi J Pharm 20:89–194. (PMID: 10.33899/iphr.2023.142864.1056) Açar Y, Ağagündüz D, De Cicco P, Capasso R (2023) Flavonoids: their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson’s disease. Biomed Pharmacother 168:115788. https://doi.org/10.1016/j.biopha.2023.115788. (PMID: 10.1016/j.biopha.2023.11578837913731) Adinortey MB, Ansah C, Galyuon I, Nyarko A (2013) In vivo models used for evaluation of potential antigastroduodenal ulcer agents. Ulcers 2013:1–12. https://doi.org/10.1155/2013/796405. (PMID: 10.1155/2013/796405) Ağagündüz D, GençerBingöl F, Çelik E, Cemali Ö, Özenir Ç, Özoğul F, Capasso R (2022) Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions. J Transl Med 20:460. https://doi.org/10.1186/s12967-022-03609-y. (PMID: 10.1186/s12967-022-03609-y362091249548122) Ağagündüz D, Kocaadam-Bozkurt B, Bozkurt O, Sharma H, Esposito R, Özoğul F, Capasso R (2022) Microbiota alteration and modulation in Alzheimer’s disease by gerobiotics: the gut-health axis for a good mind. Biomed Pharmacother 153:113430. https://doi.org/10.1016/j.biopha.2022.113430. (PMID: 10.1016/j.biopha.2022.11343036076486) Ağagündüz D, Cocozza E, Cemali Ö, Bayazıt AD, Nanì MF, Cerqua I, Morgillo F, Saygılı SK, BerniCanani R, Amero P, Capasso R (2023) Understanding the role of the gut microbiome in gastrointestinal cancer: a review. Front Pharmacol. https://doi.org/10.3389/fphar.2023.1130562. (PMID: 10.3389/fphar.2023.1130562367621089903080) Ağagündüz D, Icer MA, Yesildemir O, Koçak T, Kocyigit E, Capasso R (2023) The roles of dietary lipids and lipidomics in gut-brain axis in type 2 diabetes mellitus. J Transl Med 21:240. https://doi.org/10.1186/s12967-023-04088-5. (PMID: 10.1186/s12967-023-04088-53700987210068184) Andreou I, Tousoulis D, Miliou A, Tentolouris C, Zisimos K, Gounari P, Siasos G, Papageorgiou N, Papadimitriou CA, Dimopoulos MA, Stefanadis C (2010) Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study. Atherosclerosis 210:194–198. https://doi.org/10.1016/j.atherosclerosis.2009.10.046. (PMID: 10.1016/j.atherosclerosis.2009.10.04619962701) Ansari JA, Bhandari U, Haque SE, Pillai KK (2012) Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats. Toxicol Mech Methods 22:67–73. https://doi.org/10.3109/15376516.2011.603391. (PMID: 10.3109/15376516.2011.60339121859367) Bancroft JD, Layton C (2019) The hematoxylin and eosin. In: Suvarna SK, Layton C, Bancroft JD (eds) Bancroft’s theory and practice of histological techniques, 8th edn. Elsevier, Philadelphia, pp 126–138. (PMID: 10.1016/B978-0-7020-6864-5.00010-4) Begg M, Tarhuni M, Fotso NM, Gonzalez NA, Sanivarapu RR, Osman U, Latha Kumar A, Sadagopan A, Mahmoud A, Khan S (2023) Comparing the safety and efficacy of proton pump inhibitors and histamine-2 receptor antagonists in the management of patients with peptic ulcer disease: a systematic review. Cureus 15:e44341. https://doi.org/10.7759/cureus.44341. (PMID: 10.7759/cureus.443413777976510538946) Beiranvand M (2022) A review of the most common in vivo models of stomach ulcers and natural and synthetic anti-ulcer compounds: a comparative systematic study. Phytomedicine Plus 2:100264. https://doi.org/10.1016/j.phyplu.2022.100264. (PMID: 10.1016/j.phyplu.2022.100264) Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888. (PMID: 13967893) Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 94:329–354. https://doi.org/10.1152/physrev.00040.2012. (PMID: 10.1152/physrev.00040.2012246923504044300) Bode C, Christian Bode J (2003) Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 17(4):575–592. https://doi.org/10.1016/S1521-6918(03)00034-9. (PMID: 10.1016/S1521-6918(03)00034-912828956) Dash VB (2001) Herbal Treatment for Peptic Ulcer (Herbal Cure). B Jain Publishers Pvt Ltd 21 N New Delhi India. Dolkart O, Amar E, Shapira S, Marmor S, Steinberg EL, Weinbroum AA (2015) Protective effects of rosuvastatin in a rat model of lung contusion: stimulation of the cyclooxygenase 2–prostaglandin E-2 pathway. Surgery 157:944–953. https://doi.org/10.1016/j.surg.2014.12.017. (PMID: 10.1016/j.surg.2014.12.01725724093) Dykstra MJ, Reuss LE (2003) Biological electron microscopy. Theory techniques and troubleshooting, 2nd edn. Springer, Boston, MA US. Engen PA, Green SJ, Voigt RM, Forsyth CB, Keshavarzian A (2015) The gastrointestinal microbiome: alcohol effects on the composition of intestinal microbiota. Alcohol Res 37:223–236. (PMID: 266957474590619) Feng A, Chuang E, Wu SH, Wang JC, Chang SN, Lin CL, Kao CH (2015) The effect of statins on the occurrence of peptic ulcer. Eur J Intern Med 26:731–735. https://doi.org/10.1016/j.ejim.2015.07.015. (PMID: 10.1016/j.ejim.2015.07.01526226858) Fujii T, Nakabayashi T, Hashimoto S, Kuwano H (2009) Statin use and risk of gastroduodenal ulcer and reflux esophagitis. Hepatogastroenterology 56:641–644. (PMID: 19621671) Gebrayel P, Nicco C, Al Khodor S, Bilinski J, Caselli E, Comelli EM, Egert M, Giaroni C, Karpinski TM, Loniewski I, Mulak A, Reygner J, Samczuk P, Serino M, Sikora M, Terranegra A, Ufnal M, Villeger R, Pichon C, Konturek P, Edeas M (2022) Microbiota medicine: towards clinical revolution. J Transl Med 20:111. https://doi.org/10.1186/s12967-022-03296-9. (PMID: 10.1186/s12967-022-03296-9352559328900094) Ghaisas MM, Dandawate PR, Zawar SA, Ahire YS, Gandhi SP (2010) Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models. Inflammopharmacology 18:169–177. https://doi.org/10.1007/s10787-010-0044-6. (PMID: 10.1007/s10787-010-0044-620532641) Günbatan T, Gürbüz İ, Bedir E, GençlerÖzkan AM, Özçınar Ö (2020) Investigations on the antiulcerogenic activity of Sideritis caesarea H Duman Aytaç & Başer. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2020.112920. (PMID: 10.1016/j.jep.2020.11292032360801) Haber PS, Kortt NC (2021) Alcohol use disorder and the gut. Addiction 116:658–667. https://doi.org/10.1111/add.15147. (PMID: 10.1111/add.1514732511812) Holdgate GA, Ward WHJ, McTaggart F (2003) Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin. Biochem Soc Trans 31:528–531. https://doi.org/10.1042/bst0310528. (PMID: 10.1042/bst031052812773150) Hsia J, MacFadyen JG, Monyak J, Ridker PM (2011) Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. J Am Coll Cardiol 57:1666–1675. https://doi.org/10.1016/j.jacc.2010.09.082. (PMID: 10.1016/j.jacc.2010.09.08221492764) Hu Y, Wang X, Ye L, Li C, Chen W, Cheng H (2020) Rosuvastatin Alleviates intestinal injury by down-regulating the CD40 pathway in the intestines of rats following traumatic brain injury. Front Neurol 11:816. https://doi.org/10.3389/fneur.2020.00816. (PMID: 10.3389/fneur.2020.00816328492467431906) Ismail IF, Golbabapour S, Hassandarvish P, Hajrezaie M, Abdul Majid N, Kadir FA, Al-Bayaty F, Awang K, Hazni H, Abdulla MA (2012) Gastroprotective activity of polygonum chinense aqueous leaf extract on ethanol-induced hemorrhagic mucosal lesions in rats. Evidence-Based Complement Altern Med 2012:1–9. https://doi.org/10.1155/2012/404012. (PMID: 10.1155/2012/404012) Jowkar F, Namazi MR (2010) Statins in dermatology. Int J Dermatol 49:1235–1243. https://doi.org/10.1111/j.1365-4632.2010.04579.x. (PMID: 10.1111/j.1365-4632.2010.04579.x20964647) Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, Piscitelli F, Abolghasemi A, Gazzerro E, Silvestri C, Capasso R, Motta A, Russo R, Di Marzo V, Iannotti FA (2023) Targeting gut dysbiosis against inflammation and impaired autophagy in duchenne muscular dystrophy. EMBO Mol Med. https://doi.org/10.15252/emmm.202216225. (PMID: 10.15252/emmm.202216225365942439994484) Kamar SS, Latif NSA, Elrefai MFM, Amin SN (2020) Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats. Anat Cell Biol 53:301–312. https://doi.org/10.5115/acb.20.055. (PMID: 10.5115/acb.20.055329932807527116) Kostapanos MS, Milionis HJ, Elisaf MS (2010) Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia. Am J Cardiovasc Drugs 10:11–28. https://doi.org/10.2165/13168600-000000000-00000. (PMID: 10.2165/13168600-000000000-0000020104931) Kwak B, Mulhaupt F, Myit S, Mach F (2000) Statins as a newly recognized type of immunomodulator. Nat Med 6:1399–1402. https://doi.org/10.1038/82219. (PMID: 10.1038/8221911100127) Layton C, Bancroft JD (2019) Carbohydrates. In: Suvarna S, Layton C, Bancroft J (eds) Bancroft’s theory and practice of histological techniques (8th edn). Elsevier, Philadelphia, pp 76–197. Li YF, Zhu BW, Chen T, Chen LH, Wu D, Hu JN (2024) Construction of magnolol nanoparticles for alleviation of ethanol-Induced acute gastric injury. J Agric Food Chem Chem. https://doi.org/10.1021/acs.jafc.3c09902. (PMID: 10.1021/acs.jafc.3c09902) Ligumsky M, Sestieri M, Okon E, Ginsburg I (1995) Antioxidants inhibit ethanol-induced gastric injury in the rat: role of manganese, glycine, and carotene. Scand J Gastroenterol 30:854–860. https://doi.org/10.3109/00365529509101591. (PMID: 10.3109/003655295091015918578183) Lin CJ, Liao WC, Chen YA, Lin HJ, Feng CL, Lin CL, Lin YJ, Kao MC, Huang MZ, Lai CH, Kao CH (2017) Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population. Front Pharmacol. https://doi.org/10.3389/fphar.2017.00210. (PMID: 10.3389/fphar.2017.00210293589205744014) Liu J, Wang F, Luo H, Liu A, Li K, Li C, Jiang Y (2016) Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms. Int Immunopharmacol 30:179–187. https://doi.org/10.1016/j.intimp.2015.11.018. (PMID: 10.1016/j.intimp.2015.11.01826604089) Liu T, Zhang L, Joo D, Sun SC (2017) NF-κB signaling in inflammation. Signal Transduct Target Ther 2:17023. https://doi.org/10.1038/sigtrans.2017.23. (PMID: 10.1038/sigtrans.2017.23291589455661633) Mahalwar R, Khanna D (2013) Pleiotropic antioxidant potential of rosuvastatin in preventing cardiovascular disorders. Eur J Pharmacol 711:57–62. https://doi.org/10.1016/j.ejphar.2013.04.025. (PMID: 10.1016/j.ejphar.2013.04.02523648561) Manal AA, Yasser IK, Manal MA (2021) Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats. J Tradit Chinese Med 41:270–275. Marta Ż, Agnieszka W, Jacek P, Jeleń A, Adrian K, Dagmara SK, Sałagacka-Kubiak A, Balcerczak E (2020) NFKB2 gene expression in patients with peptic ulcer diseases and gastric cancer. Mol Biol Rep 47:2015–2021. https://doi.org/10.1007/s11033-020-05299-5. (PMID: 10.1007/s11033-020-05299-532056043) Miersch S, Sliskovic I, Raturi A, Mutus B (2007) Antioxidant and antiplatelet effects of rosuvastatin in a hamster model of prediabetes. Free Radic Biol Med 42:270–279. https://doi.org/10.1016/j.freeradbiomed.2006.10.045. (PMID: 10.1016/j.freeradbiomed.2006.10.04517189832) Mohammadi F, Harofteh FZ, Sahebnasagh A, Ghaneei N, Ardakani MEZ, Saghafi F (2024) Efficacy and safety of topical rosuvastatin & amp melatonin vs placebo in patients with mild to moderate plaque psoriasis: a preliminary randomized double-blinded clinical trial. Ski Res Technol. https://doi.org/10.1111/srt.13689. (PMID: 10.1111/srt.13689) Mumtaz H, Ghafoor B, Saghir H, Tariq M, Dahar K, Ali SH, Waheed ST, Syed AA (2022) Association of Vitamin B12 deficiency with long-term PPIs use: a cohort study. Ann Med Surg 82:104762. https://doi.org/10.1016/j.amsu.2022.104762. (PMID: 10.1016/j.amsu.2022.104762) Naito Y, Katada K, Takagi T, Tsuboi H, Kuroda M, Handa O, Kokura S, Yoshida N, Ichikawa H, Yoshikawa T (2006) Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein. World J Gastroenterol 12:2024–2030. https://doi.org/10.3748/wjg.v12.i13.2024. (PMID: 10.3748/wjg.v12.i13.2024166100514087679) Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358. https://doi.org/10.1016/0003-2697(79)90738-3. (PMID: 10.1016/0003-2697(79)90738-336810) Onen SH, Onen F, Mangeon JP, Abidi H, Courpron P, Schmidt J (2005) Alcohol abuse and dependence in elderly emergency department patients. Arch Gerontol Geriatr 41:191–200. https://doi.org/10.1016/j.archger.2005.02.002. (PMID: 10.1016/j.archger.2005.02.00216085071) Park H, Cho D, Huang E, Seo JY, Kim WG, Todorov SD, Ji Y, Holzapfel WH (2020) Amelioration of alcohol induced gastric ulcers through the administration of lactobacillus plantarum apsulloc 331261 isolated from green tea. Front Microbiol. https://doi.org/10.3389/fmicb.2020.00420. (PMID: 10.3389/fmicb.2020.00420336336977714715) Piñón-Simental JS, Ayala-Ruiz LA, Ortega-Pérez LG, Magaña-Rodríguez OR, Meléndez-Herrera E, Aguilera-Méndez A, Rios-Chavez P (2024) Use of Callistemon citrinus as a gastroprotective and anti-inflammatory agent on indomethacin-induced gastric ulcers in obese rats. PeerJ 12:e17062. https://doi.org/10.7717/peerj.17062. (PMID: 10.7717/peerj.170623843599210908265) Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Gastroenterology 77:433–443. https://doi.org/10.1016/0016-5085(79)90002-7. (PMID: 10.1016/0016-5085(79)90002-7456839) Saadat S, Boskabady MH (2021) Anti-inflammatory and antioxidant effects of rosuvastatin on asthmatic, hyperlipidemic, and asthmatic-hyperlipidemic rat models. Inflammation 44:2279–2290. https://doi.org/10.1007/s10753-021-01499-8. (PMID: 10.1007/s10753-021-01499-834226988) Sanderson T, Wild G, Cull AM, Marston J, Zardin G (2019) Immunohistochemical and Immunofluoresent techniques. Bancroft’s Theory and Practice of Histological Techniques, 8th edn. Elsevier, Phialdelphia, pp 337–396. (PMID: 10.1016/B978-0-7020-6864-5.00019-0) Shin SK, Cho JH, Kim EJ, Kim E-K, Park DK, Kwon KA, Chung J-W, Kim KO, Kim YJ (2017) Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model. World J Gastroenterol 23:4559. https://doi.org/10.3748/wjg.v23.i25.4559. (PMID: 10.3748/wjg.v23.i25.4559287403445504371) Singh S, Khajuria A, Taneja SC, Khajuria RK, Singh J, Johri RK, Qazi GN (2008) The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine 15:408–415. https://doi.org/10.1016/j.phymed.2008.02.017. (PMID: 10.1016/j.phymed.2008.02.01718424019) Takeuchi K, Kato S, Amagase K (2010) Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity. J Pharmacol Sci 114:248–261. https://doi.org/10.1254/jphs.10R06CR. (PMID: 10.1254/jphs.10R06CR21041985) Tariq M, Khan HA, Elfaki I, Arshaduddin M, Al Moutaery M, Al Rayes H, Al Swailam R (2007) Gastric antisecretory and antiulcer effects of simvastatin in rats. J Gastroenterol Hepatol 22:2316–2323. https://doi.org/10.1111/j.1440-1746.2007.05021.x. (PMID: 10.1111/j.1440-1746.2007.05021.x17593225) Tarnawski A, Ahluwalia AK, Jones M (2012) Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids. Curr Pharm Des 19:126–132. https://doi.org/10.2174/13816128130117. (PMID: 10.2174/13816128130117) Wallace JL (2000) How do NSAIDs cause ulcer disease? Best Pract Res Clin Gastroenterol 14:147–159. https://doi.org/10.1053/bega.1999.0065. (PMID: 10.1053/bega.1999.0065) Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 7:687–692. https://doi.org/10.1038/89058. (PMID: 10.1038/8905811385505) Yang S, Liu G, Xia X, Gan D, Xiang S, Xiang M (2024) α-Mangostin suppresses ethanol-induced gastric ulceration by regulating the Nrf2/HO-1 and NF-κB/NLRP3/caspase-1 signaling pathways and gut microbiota. Heliyon 10:e24339. https://doi.org/10.1016/j.heliyon.2024.e24339. (PMID: 10.1016/j.heliyon.2024.e243393830479710831614) Zhang Y, Yuan Z, Chai J, Zhu D, Miao X, Zhou J, Gu X (2023) ALDH2 ameliorates ethanol-induced gastric ulcer through suppressing NLPR3 inflammasome activation and ferroptosis. Arch Biochem Biophys 743:109621. https://doi.org/10.1016/j.abb.2023.109621. (PMID: 10.1016/j.abb.2023.10962137209766) |
| فهرسة مساهمة: | Keywords: Ethanol; Gastric ulcer; Myeloperoxidase; Nuclear factor kappa B; Rosuvastatin; Scanning electron microscopy; Statins |
| المشرفين على المادة: | 3K9958V90M (Ethanol) 83MVU38M7Q (Rosuvastatin Calcium) 0 (Antioxidants) 0 (Anti-Ulcer Agents) K7Q1JQR04M (Dinoprostone) EC 1.11.1.7 (Peroxidase) |
| تواريخ الأحداث: | Date Created: 20240723 Date Completed: 20240921 Latest Revision: 20240921 |
| رمز التحديث: | 20240922 |
| DOI: | 10.1007/s10787-024-01513-z |
| PMID: | 39044068 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5608 |
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| DOI: | 10.1007/s10787-024-01513-z |