دورية أكاديمية
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Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.

التفاصيل البيبلوغرافية
العنوان: Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.
المؤلفون: Yao Y; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Wang B; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China.; Key Laboratory for Reproductive Medicine and Embryo of Gansu, No. 1, Donggang West Road, Chengguan District, Lanzhou, Gansu Province, China., Yu K; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Song J; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China.; Key Laboratory for Reproductive Medicine and Embryo of Gansu, No. 1, Donggang West Road, Chengguan District, Lanzhou, Gansu Province, China., Wang L; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China.; Key Laboratory for Reproductive Medicine and Embryo of Gansu, No. 1, Donggang West Road, Chengguan District, Lanzhou, Gansu Province, China., Zhang X; Reproductive Medicine Center, The First Hospital of Lanzhou University, Lanzhou, China. zhangxueh@lzu.edu.cn.; Key Laboratory for Reproductive Medicine and Embryo of Gansu, No. 1, Donggang West Road, Chengguan District, Lanzhou, Gansu Province, China. zhangxueh@lzu.edu.cn., Li Y; Department of Anesthesiology, The First Hospital of Lanzhou University, No. 1, Donggang West Road, Chengguan District, Lanzhou, Gansu Province, China. liyul@lzu.edu.cn.
المصدر: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2024 Jul 23; Vol. 22 (1), pp. 86. Date of Electronic Publication: 2024 Jul 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Nuclear Receptor Subfamily 4, Group A, Member 1*/genetics , Nuclear Receptor Subfamily 4, Group A, Member 1*/metabolism , Mitophagy*/physiology , Apoptosis*/physiology , Apoptosis*/genetics , Ovary*/metabolism , Aging*/physiology , Aging*/genetics, Animals ; Female ; Mice ; Oxidative Stress/physiology ; Signal Transduction/physiology ; Ovarian Reserve/physiology ; Reproduction/physiology ; Proto-Oncogene Proteins c-akt/metabolism ; Mice, Inbred C57BL
مستخلص: Reproductive aging not only affects the fertility and physical and mental health of women but also accelerates the aging process of other organs. There is an urgent need newfor novel mechanisms, targets, and drugs to break the vicious cycle of mitochondrial dysfunction, redox imbalance, and germ cell apoptosis associated with ovarian aging. Autophagy, recognized as a longevity mechanism, has recently become a focal point in anti-aging research. Although mitophagy is a type of autophagy, its role and regulatory mechanisms in ovarian aging, particularly in age-related ovarian function decline, remain unclear. Nerve growth factor inducible gene B (Nur77) is an early response gene that can be stimulated by oxidative stress, DNA damage, metabolism, and inflammation. Recent evidence recommends that decreased expression of Nur77 is associated with age-related myocardial fibrosis, renal dysfunction, and Parkinson's disease; however, its association with ovarian aging has not been studied yet. We herein identified Nur77 as a regulator of germ cell senescence, apoptosis, and mitophagy and found that overexpression of Nur77 can activate mitophagy, improve oxidative stress, reduce apoptosis, and ultimately enhance ovarian reserve in aged mice ovaries. Furthermore, we discovered an association between Nur77 and the AKT pathway through String and molecular docking analyses. Experimental confirmation revealed that the AKT/mTOR signaling pathway is involved in the regulation of Nur77 in ovarian function. In conclusion, our results suggest Nur77 as a promising target for preventing and treating ovarian function decline related to reproductive aging.
(© 2024. The Author(s).)
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معلومات مُعتمدة: ldyyyn2021-67 Fund of the First Hospital of Lanzhou University; 2023-11-3 Lanzhou Chengguan District Science and Technology Plan Project
فهرسة مساهمة: Keywords: Aging; Apoptosis; Granulosa cells; Mitophagy; Nur77; PINK1/Parkin
المشرفين على المادة: 0 (Nuclear Receptor Subfamily 4, Group A, Member 1)
0 (Nr4a1 protein, mouse)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
تواريخ الأحداث: Date Created: 20240723 Date Completed: 20240724 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC11265396
DOI: 10.1186/s12958-024-01250-6
PMID: 39044215
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-7827
DOI:10.1186/s12958-024-01250-6