دورية أكاديمية
Synthesis and Characterization of Guanidinylated CO-Releasing Micelles Based on Biodegradable Polycarbonate.
| العنوان: | Synthesis and Characterization of Guanidinylated CO-Releasing Micelles Based on Biodegradable Polycarbonate. |
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| المؤلفون: | Li Z; Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China., Wang S; Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China., Zhao L; Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China., Feng S; Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China., Che H; Department of Chemical Engineering, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China. |
| المصدر: | Biomacromolecules [Biomacromolecules] 2024 Aug 12; Vol. 25 (8), pp. 5149-5159. Date of Electronic Publication: 2024 Jul 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2000- |
| مواضيع طبية MeSH: | Micelles* , Carbon Monoxide*/chemistry , Polycarboxylate Cement*/chemistry, Humans ; Guanidine/chemistry ; Drug Carriers/chemistry ; Drug Carriers/chemical synthesis ; Polymers/chemistry ; Dioxanes/chemistry |
| مستخلص: | As one of the gaseous signals in living cells, carbon monoxide (CO) not only participates in many biological activities but also serves as a therapeutic agent for the treatment of diseases. However, the limited applicability of CO in gas therapy emerges from the inconvenience of direct administration of CO. Here we reported the construction of guanidinylated CO-releasing micelles, which are composed of poly(trimethylene carbonate) (PTMC)-based CO donors. The in vitro studies demonstrated that micelles in the presence of light irradiation can induce cancer death, whereas no obvious toxicity to normal cells was observed. Moreover, the functionalization of guanidine groups imparts improved cellular uptake efficiency to micelles owing to the specific interactions with the surface of cells, which synergistically increase the anticancer capacity of the system. The guanidine-functionalized CO-releasing micelles provide a new strategy for the construction of CO-releasing nanocarriers, which are expected to find applications in gas therapeutics. |
| المشرفين على المادة: | 0 (Micelles) 7U1EE4V452 (Carbon Monoxide) 0 (Polycarboxylate Cement) 25766-59-0 (polycarbonate) JU58VJ6Y3B (Guanidine) 0 (Drug Carriers) 0 (Polymers) 0 (Dioxanes) 31852-84-3 (polytrimethylene carbonate) |
| تواريخ الأحداث: | Date Created: 20240724 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1021/acs.biomac.4c00542 |
| PMID: | 39045816 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1526-4602 |
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| DOI: | 10.1021/acs.biomac.4c00542 |