التفاصيل البيبلوغرافية
| العنوان: |
Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues. |
| المؤلفون: |
Ghasemzadeh-Hasankolaei M; CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jmano@ua.pt., Pinheiro D; CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jmano@ua.pt., Nadine S; CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jmano@ua.pt., Mano JF; CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jmano@ua.pt. |
| المصدر: |
Soft matter [Soft Matter] 2024 Aug 14; Vol. 20 (32), pp. 6313-6326. Date of Electronic Publication: 2024 Aug 14. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101295070 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-6848 (Electronic) Linking ISSN: 1744683X NLM ISO Abbreviation: Soft Matter Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Cambridge, England : Royal Society of Chemistry, 2005- |
| مواضيع طبية MeSH: |
Tissue Engineering* , Cellular Microenvironment* , Biomimetics*/methods, Humans ; Animals ; Biomimetic Materials/chemistry ; Biocompatible Materials/chemistry |
| مستخلص: |
The regulation of cellular behavior within a three-dimensional (3D) environment to execute a specific function remains a challenge in the field of tissue engineering. In native tissues, cells and matrices are arranged into 3D modular units, comprising biochemical and biophysical signals that orchestrate specific cellular activities. Modular tissue engineering aims to emulate this natural complexity through the utilization of functional building blocks with unique stimulation features. By adopting a modular approach and using well-designed biomaterials, cellular microenvironments can be effectively decoupled from their macro-scale surroundings, enabling the development of engineered tissues with enhanced multifunctionality and heterogeneity. We overview recent advancements in decoupling the cellular micro-scale niches from their macroenvironment and evaluate the implications of this strategy on cellular and tissue functionality. |
| المشرفين على المادة: |
0 (Biocompatible Materials) |
| تواريخ الأحداث: |
Date Created: 20240725 Date Completed: 20240814 Latest Revision: 20240814 |
| رمز التحديث: |
20240814 |
| DOI: |
10.1039/d4sm00276h |
| PMID: |
39049813 |
| قاعدة البيانات: |
MEDLINE |
