دورية أكاديمية
Engineering High-Performance Composite Cellulose Materials for Fast Hemostasis.
| العنوان: | Engineering High-Performance Composite Cellulose Materials for Fast Hemostasis. |
|---|---|
| المؤلفون: | Wang B; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.; Sanya Institute of China Agricultural University, Sanya 572025, China., Li X; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China., Wei L; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.; Sanya Institute of China Agricultural University, Sanya 572025, China., Ma S; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China., Wang J; CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China., Zhu W; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.; Sanya Institute of China Agricultural University, Sanya 572025, China., Wang H; Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.; Sanya Institute of China Agricultural University, Sanya 572025, China. |
| المصدر: | ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Aug 12; Vol. 10 (8), pp. 5313-5326. Date of Electronic Publication: 2024 Jul 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, [2015]- |
| مواضيع طبية MeSH: | Cellulose*/chemistry , Hemostatics*/chemistry , Hemostatics*/pharmacology , Hemostasis*/drug effects, Porosity ; Animals ; Blood Coagulation/drug effects ; Freeze Drying ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction ; Humans ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Gelatin/chemistry |
| مستخلص: | The development of an effective hemostatic agents is of vital importance for saving wounded individuals from uncontrolled hemorrhage, which is the main reason for preventable death after accidental injury. However, current high-performance hemostatic agents suffer from a cumbersome preparation procedures and poor biocompatibility. Here, we engineered a cellulosic-derived aerogel material by simply controlling the drying process of cellulose regeneration for fast hemostasis. Four different freeze-drying pretreatments were investigated. As compared with the other three, the cellulosic aerogel material prepared without freezing pretreatment exhibited the lowest crystallinity (21.3%) and the highest body fluid absorption capacity (20.3 times that of its own weight) due to its super hierarchical porous structure, which led to an excellent hemostatic performance in vitro blood coagulation (≈100 s). Moreover, the addition of gelatin and diatomite in the material could tune the functional groups and electrostatic properties of the aerogel and further enhance its hemostatic performance. Various characterizations, including X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), X-ray nanocomputed tomography (CT), scanning electron microscopy (SEM), and zeta potential analysis, were carried out to probe the structure-function relationship of the prepared material, and its mechanism of fast hemostasis was thereafter revealed. The results indicate that the developed aerogel is a cost-effective and feasibly scalable hemostatic material suitable for practical use in industry. |
| فهرسة مساهمة: | Keywords: biomass; biomaterials; cellulose; hemostatic agent; pretreatment |
| المشرفين على المادة: | 9004-34-6 (Cellulose) 0 (Hemostatics) 0 (Biocompatible Materials) 9000-70-8 (Gelatin) |
| تواريخ الأحداث: | Date Created: 20240725 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1021/acsbiomaterials.4c01045 |
| PMID: | 39051461 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2373-9878 |
|---|---|
| DOI: | 10.1021/acsbiomaterials.4c01045 |