دورية أكاديمية
أعرض في EDS

Cerebrospinal fluid neurofilament light chain in acute optic neuritis and its predictive ability of multiple sclerosis.

التفاصيل البيبلوغرافية
العنوان: Cerebrospinal fluid neurofilament light chain in acute optic neuritis and its predictive ability of multiple sclerosis.
المؤلفون: Passali M; Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark. moschoula.passali@regionh.dk.; Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark. moschoula.passali@regionh.dk., Galea I; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Knudsen MH; Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.; Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark., Lau LC; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Cramer SP; Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark., Frederiksen JL; Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet-Glostrup, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
المصدر: Journal of neurology [J Neurol] 2024 Sep; Vol. 271 (9), pp. 6127-6135. Date of Electronic Publication: 2024 Jul 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York, Springer-Verlag
مواضيع طبية MeSH: Optic Neuritis*/cerebrospinal fluid , Optic Neuritis*/diagnosis , Multiple Sclerosis*/cerebrospinal fluid , Multiple Sclerosis*/diagnosis , Neurofilament Proteins*/cerebrospinal fluid, Humans ; Male ; Female ; Adult ; Middle Aged ; Biomarkers/cerebrospinal fluid ; Magnetic Resonance Imaging ; Disease Progression
مستخلص: Background: Studies on the capability of cerebrospinal fluid neurofilament light chain (cNfL) to predict multiple sclerosis (MS) conversion in clinically isolated syndromes have yielded varying results.
Objectives: To expand our understanding of cNfL in optic neuritis (ON) and investigate whether incorporating cNfL into the 2017 McDonald criteria could accelerate the diagnosis of MS in patients with ON.
Methods: cNfL was measured in diagnostic samples from 74 patients with verified ON. MS was diagnosed using the 2017 McDonald criteria with a minimum observation time of two years from ON onset.
Results: 20.5% of 44 MS-converters did not fulfil the 2017 McDonald criteria at ON onset. A doubling of cNfL was associated with 207% (74%-514%) higher odds of MS (p = 0.00042, adjusted for age). Fulfilment of ≥ 1 MRI criterion for dissemination in space (DIS) and presence of brain contrast-enhancing lesions were associated with higher cNfL. Furthermore, cNfL correlated with inter-eye differences in retinal nerve fiber layer (RNFL) thickness (Spearman's ρ = 0.46, p = 8 × 10 -5 ). Incorporating cNfL ≥ 906 pg/mL as a substitute for either dissemination in time or one MRI criterion for DIS increased the sensitivity (90.9% vs. 79.6%) and accuracy (91.9% vs. 87.8%), but also reduced the specificity (93.3% vs. 100%) of the 2017 McDonald criteria.
Conclusion: cNfL was related to MS diagnostic parameters and the degree of RNFL swelling. Clinical use of cNfL may aid in identification of ON patients with increased risk of MS until larger studies have elaborated on the potential loss of specificity if used diagnostically.
(© 2024. The Author(s).)
References: Mult Scler. 2015 Apr;21(5):550-61. (PMID: 25732842)
PLoS One. 2018 Apr 3;13(4):e0194828. (PMID: 29614113)
Neurology. 2016 Sep 13;87(11):1076-84. (PMID: 27521440)
Lancet Neurol. 2018 Feb;17(2):162-173. (PMID: 29275977)
Neurology. 1999 Aug 11;53(3):473-8. (PMID: 10449106)
JAMA Neurol. 2019 Sep 01;76(9):1035-1048. (PMID: 31206160)
BMC Bioinformatics. 2011 Mar 17;12:77. (PMID: 21414208)
Bosn J Basic Med Sci. 2022 Sep 16;22(5):699-706. (PMID: 35490364)
J Neuroinflammation. 2019 Mar 11;16(1):59. (PMID: 30857557)
EBioMedicine. 2020 Jun;56:102807. (PMID: 32460167)
J Clin Med. 2022 Jul 15;11(14):. (PMID: 35887886)
Neurology. 2022 Jan 4;98(1):e1-e14. (PMID: 34716250)
Mult Scler. 2013 Apr;19(4):436-42. (PMID: 22917689)
Mult Scler. 2015 Dec;21(14):1761-70. (PMID: 25698172)
Nat Rev Neurol. 2024 May;20(5):269-287. (PMID: 38609644)
Neurology. 2009 Apr 14;72(15):1322-9. (PMID: 19365053)
Mult Scler. 2019 Jun;25(7):958-967. (PMID: 29774770)
Eur J Neurol. 2017 May;24(5):703-712. (PMID: 28261960)
Mult Scler. 2012 Aug;18(8):1081-91. (PMID: 22252467)
J Neuroimmunol. 2013 Sep 15;262(1-2):113-20. (PMID: 23870535)
Lancet Neurol. 2022 Dec;21(12):1120-1134. (PMID: 36179757)
J Neurol. 2022 Oct;269(10):5382-5394. (PMID: 35608658)
Neurology. 2023 Sep 26;101(13):e1280-e1292. (PMID: 37468284)
Mult Scler. 2016 Apr;22(5):590-8. (PMID: 26283696)
معلومات مُعتمدة: A38270 Scleroseforeningen; A40110 Scleroseforeningen; A42545 Scleroseforeningen
فهرسة مساهمة: Keywords: Biomarkers; Clinically isolated syndrome; Early diagnosis; Multiple sclerosis; Neurofilament light chain; Optic neuritis
المشرفين على المادة: 0 (Neurofilament Proteins)
0 (neurofilament protein L)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240725 Date Completed: 20240905 Latest Revision: 20240910
رمز التحديث: 20240910
مُعرف محوري في PubMed: PMC11377639
DOI: 10.1007/s00415-024-12587-8
PMID: 39052040
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1459
DOI:10.1007/s00415-024-12587-8