دورية أكاديمية
أعرض في EDS

The association between airborne particulate matter (PM 2.5 ) exposure level and primary open-angle glaucoma.

التفاصيل البيبلوغرافية
العنوان: The association between airborne particulate matter (PM 2.5 ) exposure level and primary open-angle glaucoma.
المؤلفون: Ma Y; Department of Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China., Shao M; Department of Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai 200031, China., Li S; Department of Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China., Lei Y; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 20031, China., Cao W; Department of Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China. Electronic address: wgkjyk@aliyun.com., Sun X; Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China; NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 20031, China.
المصدر: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Sep 15; Vol. 283, pp. 116752. Date of Electronic Publication: 2024 Jul 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Netherlands : Elsevier
مواضيع طبية MeSH: Particulate Matter*/analysis , Glaucoma, Open-Angle* , Intraocular Pressure*/drug effects , Air Pollutants*/analysis , Air Pollutants*/toxicity , Environmental Exposure*/adverse effects, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Visual Fields/drug effects ; Air Pollution/adverse effects ; Air Pollution/statistics & numerical data ; China
مستخلص: The eye is vulnerable to the adverse effects of air pollution. Previous experimental study found that fine particulate matter (PM 2.5 ) had a direct toxic effect on intraocular tissues. However, clinical evidence for the impact of air pollutants exposure on functional and structural changes in glaucoma remains scarce. A total of 120 patients with primary open-angle glaucoma (POAG) who met the inclusion criteria were included in this retrospective study. The standardized ophthalmic examination, such as intraocular pressure (IOP), visual field, optical coherence tomography, and comprehensive physical examination, were performed. The air pollution data, including PM 2.5 concentration and air quality index (AQI), were collected. PM 2.5 and AQI for the day of the medical examination, as well as one month, and three months before the medical examination date, were investigated. In our results, higher average exposure levels for one-month and three-month, were associated with increased IOP (r=0.229, P=0.013; r=0.204, P=0.028, respectively) and decreased visual field mean sensitivity (MS) (r=-0.212, P=0.037; r=-0.305, P=0.002, respectively). PM 2.5 concentrations for the day of the medical examination was not significantly associated with ocular parameters. In multiple linear regression analysis adjusted for demographic and clinical factors, higher PM 2.5 exposure for one month was associated with elevated IOP (P=0.040, β=0.173, 95 %CI=0.008-0.337). We also found an association between PM 2.5 and MS (one-month exposure: β=-0.160, P=0.029; three-month exposure: β=-0.238, P=0.002). The logistic regression analysis found that three-month average PM 2.5 exposure level was significantly associated with the disease severity (β=0.043, P=0.025, 95 %CI=1.005-1.084). In conclusion, this study is the first to investigate the relationship between air pollution and detailed ocular parameters of POAG patients in Shanghai over a three-year period, and to explore the effects of different exposure times of PM 2.5 on glaucoma. This study found that PM 2.5 exposure was correlated with elevated IOP and decreased MS. The one-month PM 2.5 exposure level had the most significant effects on IOP. The three-month PM 2.5 exposure level was an independent risk factor for POAG severity. Current evidence suggests there may be an association between PM 2.5 exposure and POAG.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Air pollution; Intraocular pressure; Particulate matter; Primary open-angle glaucoma; Visual field
المشرفين على المادة: 0 (Particulate Matter)
0 (Air Pollutants)
تواريخ الأحداث: Date Created: 20240725 Date Completed: 20240910 Latest Revision: 20240910
رمز التحديث: 20240910
DOI: 10.1016/j.ecoenv.2024.116752
PMID: 39053180
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2414
DOI:10.1016/j.ecoenv.2024.116752