دورية أكاديمية

The Impact of Nano-Hydroxyapatite Scaffold Enrichment on Bone Regeneration In Vivo-A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: The Impact of Nano-Hydroxyapatite Scaffold Enrichment on Bone Regeneration In Vivo-A Systematic Review.
المؤلفون: Mitić D; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Čarkić J; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Jaćimović J; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Lazarević M; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Jakšić Karišik M; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Toljić B; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia., Milašin J; School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia.
المصدر: Biomimetics (Basel, Switzerland) [Biomimetics (Basel)] 2024 Jun 25; Vol. 9 (7). Date of Electronic Publication: 2024 Jun 25.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101719189 Publication Model: Electronic Cited Medium: Internet ISSN: 2313-7673 (Electronic) Linking ISSN: 23137673 NLM ISO Abbreviation: Biomimetics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2016]-
مستخلص: Objectives: In order to ensure improved and accelerated bone regeneration, nano-hydroxyapatite scaffolds are often enriched with different bioactive components to further accelerate and improve bone healing. In this review, we critically examined whether the enrichment of nHAp/polymer scaffolds with growth factors, hormones, polypeptides, microRNAs and exosomes improved new bone formation in vivo.
Materials and Methods: Out of 2989 articles obtained from the literature search, 106 papers were read in full, and only 12 articles met the inclusion criteria for this review.
Results: Several bioactive components were reported to stimulate accelerated bone regeneration in a variety of bone defect models, showing better results than bone grafting with nHAp scaffolds alone.
Conclusions: The results indicated that composite materials based on nHAp are excellent candidates as bone substitutes, while nHAp scaffold enrichment further accelerates bone regeneration. The standardization of animal models should be provided in order to clearly define the most significant parameters of in vivo studies. Only in this way can the adequate comparison of findings from different in vivo studies be possible, further advancing our knowledge on bone regeneration and enabling its translation to clinical settings.
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فهرسة مساهمة: Keywords: bioactive components; bone scaffold; nano-hydroxyapatite; regeneration; tissue engineering
تواريخ الأحداث: Date Created: 20240726 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC11274561
DOI: 10.3390/biomimetics9070386
PMID: 39056827
قاعدة البيانات: MEDLINE
الوصف
تدمد:2313-7673
DOI:10.3390/biomimetics9070386