دورية أكاديمية
The feasibility and safety of biomaterials for posterior scleral reinforcement in rabbits.
| العنوان: | The feasibility and safety of biomaterials for posterior scleral reinforcement in rabbits. |
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| المؤلفون: | Zhang WF; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China., Li BH; Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, People's Republic of China.; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Tsinghua University, Beijing, People's Republic of China., Liu ZB; Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, People's Republic of China.; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Tsinghua University, Beijing, People's Republic of China., Peng TR; Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, People's Republic of China.; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Tsinghua University, Beijing, People's Republic of China., Dai RP; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China., Yang ZK; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China., Wang YL; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China., Xiong Z; Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, People's Republic of China.; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Tsinghua University, Beijing, People's Republic of China., Wu C; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China., Zhang T; Department of Mechanical Engineering, Tsinghua University, Beijing, People's Republic of China.; Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, People's Republic of China.; 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), Tsinghua University, Beijing, People's Republic of China., Xue AQ; Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, People's Republic of China., Chen YX; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. |
| المصدر: | Biomedical materials (Bristol, England) [Biomed Mater] 2024 Aug 08; Vol. 19 (5). Date of Electronic Publication: 2024 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol, UK : Institute of Physics Pub., |
| مواضيع طبية MeSH: | Sclera* , Biocompatible Materials*/chemistry , Feasibility Studies* , Iridoids*/chemistry , Materials Testing*, Animals ; Rabbits ; Cattle ; Swine ; Sutures ; Pericardium ; Tomography, Optical Coherence ; Humans ; Cross-Linking Reagents/chemistry ; Elastic Modulus |
| مستخلص: | To explore the feasibility and safety of biomaterials for posterior scleral reinforcement (PSR) in rabbits. Decellularization and genipin crosslink were applied to the fresh bovine pericardium and porcine endocranium, and then mechanical properties, suture retention strength, and stability were tested. PSR operation was performed on 24 rabbit eyes using treated biological materials. Ophthalmic examination was performed regularly before and after PSR operation (1 week, 1 month, 3 months, 6 months). To evaluate the effectiveness, A ultrasound, diopter, and optical coherence tomography were conducted. General condition, fundus photograph, and pathological examination were recorded to evaluate the safety. Compared with genipin crosslinked bovine pericardium (Gen-BP) (21.29 ± 13.29 Mpa), genipin crosslinked porcine endocranium (Gen-PE) (34.85 ± 3.67 Mpa, P < 0.01) showed a closer elastic modulus to that of genipin crosslinked human sclera. There were no complications or toxic reactions directly related to the materials. Capillary hyperplasia, inflammatory cell infiltration, and collagen fiber deposition were observed, and the content of type I collagen fibers increased after PSR. Overall, the choroidal thickness of treated eyes was significantly thickened at different time points after PSR, which were 96.84 ± 21.08 μm, 96.72 ± 22.00 μm, 90.90 ± 16.57 μm, 97.28 ± 14.74 μm, respectively. The Gen-PE group showed changes that were almost consistent with the overall data. Gen-BP and Gen-PE are safe biological materials for PSR. The Gen-PE group demonstrated more significant advantages over the Gen-BP group in terms of material properties. (© 2024 IOP Publishing Ltd.) |
| فهرسة مساهمة: | Keywords: bovine pericardium; genipin crosslinked; porcine endocranium; posterior scleral reinforcement |
| المشرفين على المادة: | 0 (Biocompatible Materials) 0 (Iridoids) A3V2NE52YG (genipin) 0 (Cross-Linking Reagents) |
| تواريخ الأحداث: | Date Created: 20240726 Date Completed: 20240808 Latest Revision: 20240808 |
| رمز التحديث: | 20240808 |
| DOI: | 10.1088/1748-605X/ad6826 |
| PMID: | 39059433 |
| قاعدة البيانات: | MEDLINE |
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