Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients.

التفاصيل البيبلوغرافية
العنوان:	Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients.
المؤلفون:	Godefroy O; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France. golis1044@gmail.com., Weaver NA; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands., Roussel M; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France., Dorchies F; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France., Kassir R; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France., Biesbroek JM; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands.; Department of Neurology, Diakonessenhuis Hospital, Utrecht, The Netherlands., Lee KJ; Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea., Kim BJ; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Bae HJ; Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Lim JS; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee M; Department of Neurology, Hallym University Sacred Heart Hospital, Hayllm University College of Medicine, Anyang, Republic of Korea., Yu KH; Department of Neurology, Hallym University Sacred Heart Hospital, Hayllm University College of Medicine, Anyang, Republic of Korea., Aben HP; Department of Neurology, Elisabeth Tweesteden Hospital, Tilburg, The Netherlands., de Kort PLM; Department of Neurology, Elisabeth Tweesteden Hospital, Tilburg, The Netherlands., Bordet R; Department of Pharmacology, Lille University Hospital, Lille, France., Lopes R; Department of Pharmacology, Lille University Hospital, Lille, France., Dondaine T; Department of Pharmacology, Lille University Hospital, Lille, France., Biessels GJ; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht, the Netherlands., Aarabi A; Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France.
مؤلفون مشاركون:	MetaVCI map consortium
المصدر:	Journal of neurology [J Neurol] 2024 Sep; Vol. 271 (9), pp. 6147-6159. Date of Electronic Publication: 2024 Jul 26.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin ; New York, Springer-Verlag
مواضيع طبية MeSH:	Executive Function/physiology , Trail Making Test , Stroke/diagnostic imaging , Stroke/physiopathology, Humans ; Male ; Female ; Middle Aged ; Aged ; Verbal Behavior/physiology ; Brain Mapping ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain/pathology ; Adult
مستخلص:	Objectives: The few voxel-wise lesion-symptom mapping (VLSM) studies aimed at identifying the anatomy of executive function are limited by the absence of a model and by small populations. Using Trail Making Test (TMT) and verbal fluency and a model of their architectures, our objective was to identify the key structures underlying two major executive processes, set-shifting and strategic word search. Methods: We applied a validated VLSM analysis to harmonized cognitive and imaging data from 2009 ischemic stroke patients as a part of the Meta VCI Map consortium. All contrast analyses used an adjusted threshold with 2000 Freedman-Lane permutations (p ≤ 0.05). Results: The TMT parts A and B were associated with structures involved in visual-spatial processing, the motor system, the frontal lobes, and their subcortical connections. Set-shifting depended on the left dorsomedial frontal region. Both semantic and phonemic fluency tests depended on verbal output abilities and processing speed with similar slopes in different languages. The strategic search process depended on Broca's area, F2 and related tracts, temporal and deep regions. Lastly, the lesion map of set-shifting did not overlap with those of strategic word search processes. Interpretation: Our results identify the anatomical substrates of two main executive processes, revealing that they represent only a specific subpart of previously reported structures. Finally, our results indicate that executive functions depend on several specific, anatomically separable executive processes mainly operating in various parts of the frontal lobes. (© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	DGOS R1/2013/144 Direction Générale de l'offre de Soins; Vici Grant 918.16.616 Netherlands ZONMW_ ZonMw; 842003011 Netherlands ZONMW_ ZonMw
فهرسة مساهمة:	Keywords: Dementia; Executive functions; Infarct; Lesion-symptom mapping; Mild cognitive impairment; Stroke
تواريخ الأحداث:	Date Created: 20240726 Date Completed: 20240905 Latest Revision: 20240905
رمز التحديث:	20240905
DOI:	10.1007/s00415-024-12541-8
PMID:	39060618
قاعدة البيانات:	MEDLINE

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تدمد:	1432-1459
DOI:	10.1007/s00415-024-12541-8