دورية أكاديمية
أعرض في EDS

Anti-Cancer Activities of Nano Amorphous Calcium Phosphates toward Premalignant and Oral Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Anti-Cancer Activities of Nano Amorphous Calcium Phosphates toward Premalignant and Oral Cancer Cells.
المؤلفون: Herendija E; Multidisciplinary PhD Studies, University of Belgrade, Studentski Trg 1, 11000 Belgrade, Serbia., Jakšić Karišik M; Implant-Research Center, School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia., Milašin J; Implant-Research Center, School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia., Lazarević M; Implant-Research Center, School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia., Ignjatović N; Institute of Technical Sciences of the Serbian Academy of Science and Arts, Knez Mihailova 35/IV, 11000 Belgrade, Serbia.
المصدر: Biomedicines [Biomedicines] 2024 Jul 05; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Despite advancements in treatment, the squamous cell carcinoma (OSCC) patient survival rate remains stagnant. Conventional therapies have limited effectiveness, necessitating novel agents. Our study aims to synthesize and characterize amorphous calcium phosphate nanoparticles (nACPs), assess their potential cytotoxic effects on premalignant and malignant OSCC cells, and investigate possible mechanisms of action. The morphological features of nACP were investigated by field emission scanning coupled with energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), and particle size distribution (PSD). Then, we examined the effect of nACPs on nanoparticle uptake, cell adhesion, viability, invasion ability, cell cycle, and gene expression. nACP uptake was dose-dependent, induced limited selectivity in cytotoxicity between healthy and malignant cells, and affected cellular adhesion and invasion. Early apoptosis was the predominant type of cell death. The nACP effect on viability was verified by alterations in the genes associated with apoptosis and proliferation. A high concentration of nACP was shown to arrest the cell cycle progression in the G0/G1 phase of both malignant and premalignant cells. This type of nACP justifies the development of a strategy for its potential use as an anti-cancer agent and/or anti-cancer active carrier for various drugs in oral cancer treatments.
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معلومات مُعتمدة: 7750038 Science Fund of the Republic of Serbia; 451-03-66/2024-03/200175 Ministry of Science, Technological Development and Innovation of the Republic of Serbia; 451-03-66/2024-03/ 200129 Ministry of Science, Technological Development and Innovation of the Republic of Serbia
فهرسة مساهمة: Keywords: amorphous calcium phosphate; anti-cancer effect; dysplasia; oral cancer
تواريخ الأحداث: Date Created: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11274579
DOI: 10.3390/biomedicines12071499
PMID: 39062071
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines12071499