دورية أكاديمية
أعرض في EDS

Effect of Acetylsalicylic Acid on Biological Properties of Novel Cement Based on Calcium Phosphate Doped with Ions of Strontium, Copper, and Zinc.

التفاصيل البيبلوغرافية
العنوان: Effect of Acetylsalicylic Acid on Biological Properties of Novel Cement Based on Calcium Phosphate Doped with Ions of Strontium, Copper, and Zinc.
المؤلفون: Vlajić Tovilović T; School of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia., Petrović S; School of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia., Lazarević M; School of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia., Pavić A; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11 000 Belgrade, Serbia., Plačkić N; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11 000 Belgrade, Serbia., Milovanović A; Faculty of Mechanical Engineering, University of Belgrade, 11 000 Belgrade, Serbia., Milošević M; Faculty of Mechanical Engineering, University of Belgrade, 11 000 Belgrade, Serbia., Miletic V; Faculty of Medicine and Health, Sydney Dental School, University of Sydney, Surry Hills, NSW 2010, Australia., Veljović D; Faculty of Technology and Metallurgy, University of Belgrade, 11 000 Belgrade, Serbia., Radunović M; School of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 20; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Strontium*/chemistry , Strontium*/pharmacology , Calcium Phosphates*/chemistry , Calcium Phosphates*/pharmacology , Aspirin*/pharmacology , Aspirin*/chemistry , Copper*/chemistry , Zinc*/chemistry , Zinc*/pharmacology, Humans ; Animals ; Dental Cements/chemistry ; Dental Cements/pharmacology ; Biofilms/drug effects ; Materials Testing ; Zebrafish ; Dental Pulp/cytology ; Dental Pulp/drug effects ; Streptococcus mutans/drug effects ; Stem Cells/drug effects ; X-Ray Diffraction ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Proliferation/drug effects
مستخلص: This study aimed to compare the biological properties of newly synthesized cements based on calcium phosphate with a commercially used cement, mineral trioxide aggregate (MTA). Strontium (Sr)-, Copper (Cu)-, and Zinc (Zn)-doped hydroxyapatite (miHAp) powder was obtained through hydrothermal synthesis and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive X-ray spectrometry (EDX). Calcium phosphate cement (CPC) was produced by mixing miHAp powder with a 20 wt.% citric acid solution, followed by the assessment of its compressive strength, setting time, and in vitro bioactivity. Acetylsalicylic acid (ASA) was added to the CPC, resulting in CPCA. Biological tests were conducted on CPC, CPCA, and MTA. The biocompatibility of the cement extracts was evaluated in vitro using human dental pulp stem cells (hDPSCs) and in vivo using a zebrafish model. Antibiofilm and antimicrobial effect (quantified by CFUs/mL) were assessed against Streptococcus mutans and Lactobacillus rhamnosus . None of the tested materials showed toxicity, while CPCA even increased hDPSCs proliferation. CPCA showed a better safety profile than MTA and CPC, and no toxic or immunomodulatory effects on the zebrafish model. CPCA exhibited similar antibiofilm effects against S. mutans and L. rhamnosus to MTA.
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معلومات مُعتمدة: 451-03-9/2021-14/200129 Ministry of Science, Technological Development and Innovation, Republic of Serbia; 451-03-65/2024-03/200135 Ministry of Science, Technological Development and Innovation, Republic of Serbia; 451-03-66/2024-03/200042 Ministry of Science, Technological Development and Innovation, Republic of Serbia
فهرسة مساهمة: Keywords: antibiofilm; calcium phosphate; dental pulp stem cells; hydroxyapatite; zebrafish
المشرفين على المادة: YZS2RPE8LE (Strontium)
0 (Calcium Phosphates)
R16CO5Y76E (Aspirin)
789U1901C5 (Copper)
J41CSQ7QDS (Zinc)
97Z1WI3NDX (calcium phosphate)
0 (Dental Cements)
0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11276672
DOI: 10.3390/ijms25147940
PMID: 39063181
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25147940