دورية أكاديمية
أعرض في EDS

Circulating Malondialdehyde Is a Potential Biomarker for Predicting All-Cause Mortality during Follow-Up by Reflecting Comprehensive Inflammation at Diagnosis in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

التفاصيل البيبلوغرافية
العنوان: Circulating Malondialdehyde Is a Potential Biomarker for Predicting All-Cause Mortality during Follow-Up by Reflecting Comprehensive Inflammation at Diagnosis in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
المؤلفون: Chung J; Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Yoon T; Department of Medical Science, BK21 Plus Project, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Do H; Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, Republic of Korea., Park YB; Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Lee SW; Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
المصدر: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2024 Jul 21; Vol. 60 (7). Date of Electronic Publication: 2024 Jul 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga
مواضيع طبية MeSH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/blood , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/mortality , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/diagnosis , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/complications , Biomarkers*/blood , C-Reactive Protein*/analysis , Inflammation*/blood , Malondialdehyde*/blood, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Blood Sedimentation ; Cross-Sectional Studies ; Follow-Up Studies
مستخلص: Background and Objectives: To investigate whether circulating malondialdehyde (cMDA) at diagnosis could contribute to reflecting cross-sectional comprehensive inflammation or vasculitis activity and further predicting all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Materials and Methods: This study included 78 patients with AAV. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were collected as indices reflecting cross-sectional comprehensive inflammation, whereas the Birmingham vasculitis activity score (bVAS), and the five-factor score (FFS) were reviewed as AAV-specific indices. All-cause mortality was considered to be a poor outcome during follow-up. cMDA was measured from stored sera. Results: The median age of the 78 patients (32 men and 46 women) was 63.0 years. The median BVAS, FFS, ESR, and CRP were 5.0, 0, 24.5 mm/h, and 3.4 mg/L, respectively. Six patients died during the median follow-up duration based on all-cause mortality at 26.7 months. At diagnosis, cMDA was significantly correlated with cross-sectional ESR but not with BVAS or FFS. Compared to patients with cMDA < 221.7 ng/mL, those with cMDA ≥ 221.7 ng/mL at diagnosis exhibited an increased relative risk (RR 12.4) for all-cause mortality and further showed a decreased cumulative patient survival rate. Cox analyses revealed that cMDA ≥ 221.7 ng/mL (hazard ratio 24.076, p = 0.007) exhibited an independent association with all-cause mortality during follow-up in patients with AAV. Conclusions: cMDA at diagnosis may be a potential biomarker for predicting all-cause mortality during follow-up by reflecting comprehensive inflammation at diagnosis in patients with AAV.
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معلومات مُعتمدة: NCR 2019-6 CELLTRION PHARM, Inc. Chungcheongbuk-do, Republic of Korea; N/A Chong Kun Dang Pharmaceutical Corp, Seoul, Republic of Korea
فهرسة مساهمة: Keywords: antineutrophil cytoplasmic antibody; inflammation; malondialdehyde; mortality; vasculitis
المشرفين على المادة: 0 (Biomarkers)
9007-41-4 (C-Reactive Protein)
4Y8F71G49Q (Malondialdehyde)
تواريخ الأحداث: Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240813
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11278744
DOI: 10.3390/medicina60071182
PMID: 39064611
قاعدة البيانات: MEDLINE
الوصف
تدمد:1648-9144
DOI:10.3390/medicina60071182