دورية أكاديمية
Study on the effect and mechanism of Yanghe decoction Huacai on tissue repair ofsyndrome after anal fistula surgery.
| العنوان: | Study on the effect and mechanism of Yanghe decoction Huacai on tissue repair ofsyndrome after anal fistula surgery. |
|---|---|
| المؤلفون: | Yijuan WU; Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China., Xinghong S; Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China., Haixia G; Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China., Xiangan Z; Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China. |
| المصدر: | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2024 Aug; Vol. 44 (4), pp. 813-721. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy Of Traditional Chinese Medicine Country of Publication: China NLM ID: 8211546 Publication Model: Print Cited Medium: Internet ISSN: 2589-451X (Electronic) Linking ISSN: 02552922 NLM ISO Abbreviation: J Tradit Chin Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Academy Of Traditional Chinese Medicine Original Publication: [Beijing, China : Pub. Office, Journal of Traditional Chinese Medicine, 1981- |
| مواضيع طبية MeSH: | Wound Healing*/drug effects , Drugs, Chinese Herbal*/administration & dosage , Rectal Fistula*/surgery , Rectal Fistula*/drug therapy , Rectal Fistula*/metabolism , Rectal Fistula*/etiology , Rectal Fistula*/genetics , Fibroblast Growth Factor 2*/genetics , Fibroblast Growth Factor 2*/metabolism , Epidermal Growth Factor*/genetics , Epidermal Growth Factor*/metabolism , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics, Humans ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Treatment Outcome ; Aged |
| مستخلص: | Objective: To observe the clinical efficacy and safety of Yanghe decoction Huacai for the repair of Yin syndrome wounds with slow-healing after anal fistula surgery. Methods: A total of 120 patients with slow-healing negative wounds with after low-grade anal fistula surgery who met the inclusion criteria were divided into a treatment group and a control group based on a random number table method, with 60 patients in the treatment group and 60 patients in the control group. The treatment group was given Yanghe decoction Huacai in combination with routine treatment; the control group was only given routine treatment, in which the wound surface was disinfected with iodine, and then covered with sterile gauze. The course of treatment in both groups was 10 d. After treatment, the wound secretion score, wound granulation tissue score, the expression levels of basic fibroblast growth factor (bFGF), transforming growth factor β1 (TGF-β1), and epidermal growth factor (EGF) in the wound, wound healing time and clinical efficacy were compared. Results: There was no significant difference in age or gender between the two groups ( P > 0.05). On the 10th and 15th days after the surgery, the wound secretion scores were higher in the treatment group than in the control group ( P < 0.01). Comparing the two groups at the 10th and 15th day after surgery, the granulation tissue growth scores in the treatment group were better than the in control group ( P < 0.01). On the 10th and 15th day after operation, the expression levels of bFGF, TGF-β1 and EGF factors in the treatment group were stronger than those in the control group. The healing time of the wounds in the treatment group was significantly shorter than in the control group ( P < 0.01). The clinical efficacy of the two groups after treatment was compared, and the overall efficacy of the treatment group was significantly higher than that of the control group ( P < 0.01). Conclusions: Yanghe decoction Huacai have significant efficacy in the treatment of slow-healing wounds with Yin syndrome after anal fistula surgery. It improves wound secretions, promotes the growth of wound granulation tissue, and shortens wound healing time. Its mechanism of action may be related to the control of wound inflammation. It is related to increasing the expression of bFGF, TGF-β1 and EGF in wound tissue, and promoting wound angiogenesis and fibroblast proliferation. |
| معلومات مُعتمدة: | Clinical Observation of Yanghe Decoction on Tissue Repair after Anal Fistula Operation, 2017ZY2058 Special Research Project on Chinese Medicine in Henan Province; Effect and Mechanism of Yanghe Decoction on Tissue Repair after Anal Fistula Operation, 182102310289 Henan Provincial Science and Technology Tackling Project |
| فهرسة مساهمة: | Keywords: Yanghe decoction huacai; general surgery; intercellular signaling peptides and proteins; mechanism; negative wound; rectal fistula |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 103107-01-3 (Fibroblast Growth Factor 2) 62229-50-9 (Epidermal Growth Factor) 0 (Transforming Growth Factor beta1) |
| تواريخ الأحداث: | Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240728 |
| رمز التحديث: | 20240728 |
| DOI: | 10.19852/j.cnki.jtcm.20240515.004 |
| PMID: | 39066542 |
| قاعدة البيانات: | MEDLINE |
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