دورية أكاديمية
HLA-A02 restricted T-cell cross-reactivity to a microbial antigen.
| العنوان: | HLA-A02 restricted T-cell cross-reactivity to a microbial antigen. |
|---|---|
| المؤلفون: | Aints A; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Šunina M; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Uibo R; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. |
| المصدر: | Journal of immunotoxicology [J Immunotoxicol] 2024 Dec; Vol. 21 (1), pp. 2373247. Date of Electronic Publication: 2024 Jul 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101201960 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1547-6901 (Electronic) Linking ISSN: 1547691X NLM ISO Abbreviation: J Immunotoxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor & Francis Health Sciences, c2004- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 1*/immunology , HLA-A2 Antigen*/immunology , HLA-A2 Antigen*/metabolism , Antigens, Bacterial*/immunology , Glucose-6-Phosphatase*/immunology , Glucose-6-Phosphatase*/genetics , Cross Reactions*/immunology , Epitopes, T-Lymphocyte*/immunology , CD8-Positive T-Lymphocytes*/immunology, Humans ; Animals ; Mice ; Molecular Mimicry/immunology ; Mice, Inbred NOD ; Bacterial Proteins/immunology ; Cells, Cultured |
| مستخلص: | Molecular mimicry has been proposed to be a possible mechanism of induction of autoimmunity. In some cases, it is believed that such events could lead to a disease such as Type 1 diabetes (T1D). One of the primary MHC-I epitopes in the non-obese diabetic (NOD) mouse model of T1D has been identified as a peptide from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) protein. In humans, the most common MHC-I model allele is HLA-A02; based on this, the study here identified a potential HLA-A0201-restricted human IGRP epitope as YLKTNLFLFL and also found a homologous A0201-restricted peptide in an Enterococcal protein. Using cells obtained from healthy human donors, it was seen that after a 2-week incubation with the synthetic bacterial protein, healthy A0201 + donor CD8 + cells displayed increased staining for human IGRP-peptide-dextramer. On the other hand, in control cultures, no significant levels of dextramer-staining CD8 + T-cells were detectable. From these outcomes, it is possible to conclude that certain bacterial proteins may initiate CD8 + T-cell-mediated immune reaction toward homologous human antigens. |
| فهرسة مساهمة: | Keywords: Autoimmunity; Type 1 diabetes; cross-presentation; immunotoxin; molecular mimicry |
| المشرفين على المادة: | 0 (HLA-A2 Antigen) 0 (Antigens, Bacterial) EC 3.1.3.9 (Glucose-6-Phosphatase) 0 (Epitopes, T-Lymphocyte) EC 3.1.3.9. (G6PC2 protein, human) 0 (HLA-A*02:01 antigen) 0 (Bacterial Proteins) |
| تواريخ الأحداث: | Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240728 |
| رمز التحديث: | 20240729 |
| DOI: | 10.1080/1547691X.2024.2373247 |
| PMID: | 39066679 |
| قاعدة البيانات: | MEDLINE |
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