دورية أكاديمية
Acetamiprid induces cardiotoxicity in rats by dysregulating α7 nAChR and its downstream targets: The ameliorative role of resveratrol.
| العنوان: | Acetamiprid induces cardiotoxicity in rats by dysregulating α7 nAChR and its downstream targets: The ameliorative role of resveratrol. |
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| المؤلفون: | Abdelrahman RE; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Hassan MS; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Morgan AM; Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Electronic address: ashraf.m.morgan@gmail.com., Ibrahim MA; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Hassanen EI; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Sep; Vol. 191, pp. 114892. Date of Electronic Publication: 2024 Jul 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Neonicotinoids*/toxicity , Resveratrol*/pharmacology , alpha7 Nicotinic Acetylcholine Receptor*/metabolism , alpha7 Nicotinic Acetylcholine Receptor*/genetics , Cardiotoxicity*, Animals ; Male ; Rats ; Oxidative Stress/drug effects ; Insecticides/toxicity ; Myocardium/metabolism ; Apoptosis/drug effects ; Stilbenes/pharmacology |
| مستخلص: | Acetamiprid (ACP) is a novel neonicotinoid insecticide used for controlling insect pests. Resveratrol (RSV) is a natural polyphenol that possesses anti-oxidant, anti-inflammatory and anti-apoptotic actions. The current research explores the mechanism of ACP-induced cardiotoxicity and the alleviative effects of RSV. Male rats were allocated to four groups of ten each. Rats were treated daily for 90 days via oral route. Control rats received distilled water, ACP rats received 25 mg acetamiprid/kg, RSV rats received 20 mg resveratrol/kg and ACP + RSV rats received both ACP and RSV. ACP exposure increased serum creatine phosphokinase activity and cardiac troponin level. It also induced oxidative stress, as evidenced by the glutathione reduction, and malondialdehyde elevation, as well as the detrimental histopathological and immunohistochemical changes in the myocardium. Gene expression analysis revealed down-regulation in the mRNA expression of the survival-related genes α7 nAChR, Erk and Bcl-2, and up-regulation in the apoptosis-related genes Jnk, Bax and Caspase-3. Conversely, the concomitant administration of ACP with RSV alleviated most of the aforementioned toxic impacts. It can be concluded that ACP induces cardiotoxicity by dysregulating the mRNA expression of α7 nAChR and its downstream targets. Additionally, RSV is proved to be a promising ameliorative agent against ACP-induced cardiotoxicity. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Erk; Immunohistochemistry; Jnk; Oxidative stress; α7 nAChR |
| المشرفين على المادة: | 0 (Neonicotinoids) Q369O8926L (Resveratrol) 0 (alpha7 Nicotinic Acetylcholine Receptor) 5HL5N372P0 (acetamiprid) 0 (Insecticides) 0 (Stilbenes) |
| تواريخ الأحداث: | Date Created: 20240727 Date Completed: 20240816 Latest Revision: 20240816 |
| رمز التحديث: | 20240818 |
| DOI: | 10.1016/j.fct.2024.114892 |
| PMID: | 39067744 |
| قاعدة البيانات: | MEDLINE |
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