دورية أكاديمية
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The origin, deployment, and evolution of a plant-parasitic nematode effectorome.

التفاصيل البيبلوغرافية
العنوان: The origin, deployment, and evolution of a plant-parasitic nematode effectorome.
المؤلفون: Molloy B; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Shin DS; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Long J; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Pellegrin C; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Senatori B; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Vieira P; Mycology and Nematology Genetic Diversity and Biology Laboratory, United States Department of Agriculture-Agricultural Research Service, Beltsville, Maryland, United States of America., Thorpe PJ; The Data Analysis Group, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Damm A; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Ahmad M; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Vermeulen K; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Derevnina L; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Wei S; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Sperling A; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Reyes Estévez E; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Bruty S; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., de Souza VHM; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Kranse OP; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom., Maier T; Department of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, Iowa, United States of America., Baum T; Department of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, Iowa, United States of America., Eves-van den Akker S; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom.
المصدر: PLoS pathogens [PLoS Pathog] 2024 Jul 29; Vol. 20 (7), pp. e1012395. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Plant Diseases*/parasitology , Host-Parasite Interactions*, Animals ; Tylenchoidea/genetics ; Plants/parasitology ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; Nematoda/genetics
مستخلص: Plant-parasitic nematodes constrain global food security. During parasitism, they secrete effectors into the host plant from two types of pharyngeal gland cells. These effectors elicit profound changes in host biology to suppress immunity and establish a unique feeding organ from which the nematode draws nutrition. Despite the importance of effectors in nematode parasitism, there has been no comprehensive identification and characterisation of the effector repertoire of any plant-parasitic nematode. To address this, we advance techniques for gland cell isolation and transcriptional analysis to define a stringent annotation of putative effectors for the cyst nematode Heterodera schachtii at three key life-stages. We define 717 effector gene loci: 269 "known" high-confidence homologs of plant-parasitic nematode effectors, and 448 "novel" effectors with high gland cell expression. In doing so we define the most comprehensive "effectorome" of a plant-parasitic nematode to date. Using this effector definition, we provide the first systems-level understanding of the origin, deployment and evolution of a plant-parasitic nematode effectorome. The robust identification of the effector repertoire of a plant-parasitic nematode will underpin our understanding of nematode pathology, and hence, inform strategies for crop protection.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Molloy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Helminth Proteins)
تواريخ الأحداث: Date Created: 20240729 Date Completed: 20240808 Latest Revision: 20240810
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC11309470
DOI: 10.1371/journal.ppat.1012395
PMID: 39074142
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1012395