دورية أكاديمية
أعرض في EDS

Diurnal sex differences in morphine withdrawal revealed by continuous assessment of voluntary home cage wheel running in the rat.

التفاصيل البيبلوغرافية
العنوان: Diurnal sex differences in morphine withdrawal revealed by continuous assessment of voluntary home cage wheel running in the rat.
المؤلفون: Morgan MM; Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave, Vancouver, WA 98686, United States. Electronic address: mmmorgan@wsu.edu., Nguyen KD; Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave, Vancouver, WA 98686, United States.
المصدر: Behavioural brain research [Behav Brain Res] 2024 Aug 24; Vol. 472, pp. 115169. Date of Electronic Publication: 2024 Jul 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Substance Withdrawal Syndrome*/physiopathology , Morphine*/pharmacology , Morphine*/administration & dosage , Sex Characteristics* , Motor Activity*/drug effects , Motor Activity*/physiology , Circadian Rhythm*/physiology , Circadian Rhythm*/drug effects, Animals ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Narcotics/administration & dosage ; Narcotics/pharmacology ; Body Weight/drug effects ; Body Weight/physiology ; Running/physiology ; Dose-Response Relationship, Drug ; Analgesics, Opioid/pharmacology ; Analgesics, Opioid/administration & dosage
مستخلص: Animal studies modeling recreational opioid use show more severe withdrawal symptoms in male compared to female rats, whereas our study modeling opioid use for pain showed a greater withdrawal-induced decrease in wheel running in female rats. The objective of this experiment was to determine whether sex differences in spontaneous morphine withdrawal are caused by differences in assessment method (i.e., wheel running vs. somatic symptoms). Twice daily injections of morphine (5 - 20 mg/kg, s.c.) for 5 days produced a dose and time dependent decrease in wheel running that was greater in male compared to female rats. Termination of morphine administration resulted in an overall decrease in running and a decrease in the amount of running during the dark phase of the light cycle from 95 % to approximately 75 %. In male rats, this decrease in the percent of dark running was caused by a large decrease in dark phase running, whereas female rats had a slightly higher increase in light phase running. Withdrawal also reduced maximal running speed and caused a decrease in body weight that was larger in male than female rats. Withdrawal symptoms were greatest on the day following the last morphine injection, but persisted for all 3 days of assessment. Morphine withdrawal produced a greater decrease in dark phase wheel running and body weight in male rats and a greater increase in light phase running in female rats. Voluntary home cage wheel running provides a continuous measure of opioid withdrawal that is consistent with other measures of opioid withdrawal.
Competing Interests: Conflict of Interest Neither author has a conflict of interest, financial or personal, related to this manuscript.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Morphine dependence; Morphine withdrawal; Opioids; Sex difference; Wheel running
المشرفين على المادة: 76I7G6D29C (Morphine)
0 (Narcotics)
0 (Analgesics, Opioid)
تواريخ الأحداث: Date Created: 20240729 Date Completed: 20240812 Latest Revision: 20240905
رمز التحديث: 20240906
DOI: 10.1016/j.bbr.2024.115169
PMID: 39074589
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7549
DOI:10.1016/j.bbr.2024.115169