دورية أكاديمية
Prevalence of clinically significant liver fibrosis in the general population: A systematic review and meta-analysis.
| العنوان: | Prevalence of clinically significant liver fibrosis in the general population: A systematic review and meta-analysis. |
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| المؤلفون: | Kim HY; Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea., Yu JH; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., Chon YE; Department of Internal Medicine, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Kim SU; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea., Kim MN; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea., Han JW; Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea., Lee HA; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea., Jin YJ; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea., An J; Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea., Choi M; Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul, Republic of Korea., Jun DW; Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea. |
| المصدر: | Clinical and molecular hepatology [Clin Mol Hepatol] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Korea : Korean Association for the Study of the Liver |
| مستخلص: | Background/aims: Although important, clinically significant liver fibrosis is often overlooked in the general population. We aimed to examine the prevalence of clinically significant liver fibrosis using noninvasive tests (NITs) in the general population. Methods: We collected data from four databases (MEDLINE, Embase, Cochrane Library, and KoreaMed) from inception to June 13, 2023. Original articles reporting the prevalence of clinically significant liver fibrosis in the general population were included. The Stata metaprop function was used to obtain the pooled prevalence of liver fibrosis with NITs in the general population. Results: We screened 6,429 articles and included 45 eligible studies that reported the prevalence of clinically significant liver fibrosis in the general population. The prevalence of advanced liver fibrosis, using the high probability cutoff of the fibrosis-4 (FIB-4) index, was 2.3% (95% confidence interval [CI], 1.2-3.7%). The prevalence of significant liver fibrosis, advanced liver fibrosis, and liver cirrhosis, assessed using vibration-controlled transient elastography (VCTE) among the general population, was 7.3% (95% CI, 5.9-8.8%), 3.5% (95% CI, 2.7-4.5), and 1.2% (95% CI, 0.8-1.8%), respectively. Region-based subgroup analysis revealed that the highest prevalence of advanced fibrosis using the high probability cutoff of the FIB-4 index was observed in the American region. Furthermore, the American region exhibits the highest prevalence of significant liver fibrosis, advanced liver fibrosis, and liver cirrhosis, using VCTE. Conclusions: Previously undiagnosed clinically significant liver fibrosis is found in the general population through NITs. Future research is necessary to stratify the risk in the general population. |
| فهرسة مساهمة: | Keywords: liver fibrosis; meta-analysis; noninvasive test; systematic review; general population |
| تواريخ الأحداث: | Date Created: 20240729 Latest Revision: 20240731 |
| رمز التحديث: | 20240731 |
| DOI: | 10.3350/cmh.2024.0351 |
| PMID: | 39074982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2287-285X |
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| DOI: | 10.3350/cmh.2024.0351 |