Autologous matrix-induced chondrogenesis provides better outcomes in comparison to autologous minced cartilage implantation in the repair of knee chondral defects.

التفاصيل البيبلوغرافية
العنوان:	Autologous matrix-induced chondrogenesis provides better outcomes in comparison to autologous minced cartilage implantation in the repair of knee chondral defects.
المؤلفون:	Behrendt P; Department of Orthopaedics and Traumatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Anatomy, Christian-Albrechts-University, Kiel, Germany., Eggeling L; Department of Trauma Surgery, Orthopaedics and Sports Traumatology, BG Hospital Hamburg, Hamburg, Germany., Lindner A; Department of Trauma Surgery, Orthopedics and Sportsorthopedics, Asklepios St. Georg, Hamburg, Germany., von Rehlingen-Prinz F; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krause M; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hoffmann M; Department of Trauma Surgery, Orthopedics and Sportsorthopedics, Asklepios St. Georg, Hamburg, Germany., Frosch KH; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Akoto R; Department of Trauma Surgery, Orthopaedics and Sports Traumatology, BG Hospital Hamburg, Hamburg, Germany., Gille J; Department of Orthopaedic and Trauma Surgery, Regio Kliniken, Hamburg, Germany.
المصدر:	Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA [Knee Surg Sports Traumatol Arthrosc] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley Country of Publication: Germany NLM ID: 9314730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7347 (Electronic) Linking ISSN: 09422056 NLM ISO Abbreviation: Knee Surg Sports Traumatol Arthrosc Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2024- : [Hoboken] : Wiley Original Publication: [Heidelberg, Germany] : Springer International, c1993-
مستخلص:	Purpose: In symptomatic mid-sized focal chondral defects, autologous matrix-induced chondrogenesis (AMIC) and minced cartilage implantation (MCI) offer two versatile treatment options. This study aimed to conduct a matched-patient analysis of patient-reported outcome measures to compare these two surgical treatment methods for focal chondral defects. Methods: At the first centre, patients underwent a single-stage procedure in which autologous cartilage was hand-minced, implanted into the defect and fixed with fibrin glue. At the second centre, patients underwent AMIC, which was fixed in place with fibrin glue. All patients were seen 2-4 years postoperatively. Postoperative outcomes were assessed using the visual analogue scale for pain (VAS), the Lysholm score and the five domains of the knee osteoarthritis outcome score (KOOS). Patients from each surgical centre were matched by age, sex, defect size and defect localisation. Results: In total, 48 patients from two surgical centres (24 from each site) were matched for sex, age (MCI 30.3 ± 14.9 years vs. AMIC 30.8 ± 13.7 years) and defect size (MCI 2.49 ± 1.5 cm ² vs. AMIC 2.65 ± 1.1 cm ² ). Significantly better scores in the AMIC cohort were noted for VAS (p = 0.004), Lysholm (p = 0.043) and the KOOS subscales for pain (p = 0.016) and quality of life (p = 0.036). There was a significantly greater proportion of positive responders for Lysholm in the AMIC group (92%) compared with the MCI group (64%). Conclusions: The AMIC procedure delivers superior patient outcomes compared with hand-minced autologous cartilage implantation. These are mid-term outcomes, with follow-up between 2 and 4 years. Level of Evidence: Level III. (© 2024 The Author(s). Knee Surgery, Sports Traumatology, Arthroscopy published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy.)
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فهرسة مساهمة:	Keywords: AMIC; articular cartilage; autologous matrix‐induced chondrogenesis; chondral; minced cartilage
تواريخ الأحداث:	Date Created: 20240730 Latest Revision: 20240730
رمز التحديث:	20240730
DOI:	10.1002/ksa.12387
PMID:	39077845
قاعدة البيانات:	MEDLINE

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