دورية أكاديمية
أعرض في EDS

Impact of elevated serum estradiol levels before progesterone administration on pregnancy outcomes in frozen-thawed embryo transfer for hormone replacement therapy.

التفاصيل البيبلوغرافية
العنوان: Impact of elevated serum estradiol levels before progesterone administration on pregnancy outcomes in frozen-thawed embryo transfer for hormone replacement therapy.
المؤلفون: Shuai J; Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, No. 64 of Jintang Street, Chongqing, 400013, People's Republic of China., Chen Q; Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, No. 64 of Jintang Street, Chongqing, 400013, People's Republic of China., Wan S; College of Science, University of Nottingham Ningbo China, Ningbo City, Zhejiang Province, People's Republic of China., Chen X; Department of Clinical Medicine, Chongqing Medical University, Chongqing, People's Republic of China., Liu W; Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, No. 64 of Jintang Street, Chongqing, 400013, People's Republic of China., Ye H; Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, No. 64 of Jintang Street, Chongqing, 400013, People's Republic of China., Huang G; Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, No. 64 of Jintang Street, Chongqing, 400013, People's Republic of China. gnhuang217@sina.com.
المصدر: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2024 Jul 30; Vol. 22 (1), pp. 88. Date of Electronic Publication: 2024 Jul 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Embryo Transfer*/methods , Estradiol*/blood , Progesterone*/blood , Hormone Replacement Therapy*/methods , Pregnancy Outcome*/epidemiology , Pregnancy Rate* , Cryopreservation*, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Fertilization in Vitro/methods ; Live Birth/epidemiology
مستخلص: Objective: The objective of this retrospective cohort study is to investigate the impact of monitoring serum estradiol (E2) levels before progesterone administration within hormone replacement therapy (HRT) on pregnancy outcomes in women undergoing frozen-thawed embryo transfer (FET).
Methods: Analyzed HRT-FET cycles conducted at a reproductive center from 2017 to 2022. Serum E2 levels were measured prior to progesterone administration. Multivariate stratified and logistic regression analyses were performed on 26,194 patients grouped according to terciles of serum E2 levels before progesterone administration.
Results: The clinical pregnancy rate (CPR) and live birth rate (LBR) exhibited a gradual decline with increasing serum E2 levels across the three E2 groups. Even after controlling for potential confounders, including female age, body mass index, infertility diagnosis, cycle category, number of embryos transferred, fertilization method, indication for infertility, and endometrial thickness, both CPR and LBR persistently showed a gradual decrease as serum E2 levels increased within the three E2 groups. The same results were obtained by multivariate logistic regression analysis.
Conclusions: This large retrospective study indicates that elevated serum E2 levels before progesterone administration during HRT-FET cycles are associated with reduced CPR and LBR post-embryo transfer. Therefore, it is advisable to monitor serum E2 levels and adjust treatment strategies accordingly to maximize patient outcomes.
(© 2024. The Author(s).)
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معلومات مُعتمدة: the Medical Research Foundation of Chongqing, China (grant 2023MSXM054) Weiwei Liu; the National Natural Science Foundation of China, China (grant 82371728) Guoning Huang
فهرسة مساهمة: Keywords: Clinical pregnancy rate; Estradiol; Frozen-thawed embryo transfer; Hormone replacement therapy; Live birth rate
المشرفين على المادة: 4TI98Z838E (Estradiol)
4G7DS2Q64Y (Progesterone)
تواريخ الأحداث: Date Created: 20240730 Date Completed: 20240731 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC11290307
DOI: 10.1186/s12958-024-01260-4
PMID: 39080633
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-7827
DOI:10.1186/s12958-024-01260-4