دورية أكاديمية
Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface.
| العنوان: | Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface. |
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| المؤلفون: | Dumas CE; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., Rousset C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., De Bono C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., Cortés C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., Jullian E; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., Lescroart F; Aix-Marseille Université, INSERM, MMG U1251, 13005 Marseille, France., Zaffran S; Aix-Marseille Université, INSERM, MMG U1251, 13005 Marseille, France., Adachi N; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France., Kelly RG; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France. |
| المصدر: | Development (Cambridge, England) [Development] 2024 Aug 15; Vol. 151 (16). Date of Electronic Publication: 2024 Aug 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Eng : Company Of Biologists Limited Original Publication: [Cambridge] : Company of Biologists, [c1987- |
| مواضيع طبية MeSH: | Tretinoin*/metabolism , Signal Transduction* , Neck Muscles*/embryology , Muscle Development* , Mesoderm*/metabolism , Mesoderm*/embryology , Head*/embryology, Animals ; Mice ; Gene Expression Regulation, Developmental ; Somites/metabolism ; Somites/embryology ; Receptors, Retinoic Acid/metabolism |
| مستخلص: | Skeletal muscles of the head and trunk originate in distinct lineages with divergent regulatory programmes converging on activation of myogenic determination factors. Branchiomeric head and neck muscles share a common origin with cardiac progenitor cells in cardiopharyngeal mesoderm (CPM). The retinoic acid (RA) signalling pathway is required during a defined early time window for normal deployment of cells from posterior CPM to the heart. Here, we show that blocking RA signalling in the early mouse embryo also results in selective loss of the trapezius neck muscle, without affecting other skeletal muscles. RA signalling is required for robust expression of myogenic determination factors in posterior CPM and subsequent expansion of the trapezius primordium. Lineage-specific activation of a dominant-negative RA receptor reveals that trapezius development is not regulated by direct RA signalling to myogenic progenitor cells in CPM, or through neural crest cells, but indirectly through the somitic lineage, closely apposed with posterior CPM in the early embryo. These findings suggest that trapezius development is dependent on precise spatiotemporal interactions between cranial and somitic mesoderm at the head/trunk interface. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2024. Published by The Company of Biologists Ltd.) |
| معلومات مُعتمدة: | ANR-19-CE13-008 Agence Nationale de la Recherche; TNE-15CVD01 Fondation Leducq; 24396 AFM-Telethon; FTD2022040147500 Fondation pour la Recherche Medciale; Grant-in-Aid 23K06316 Japan Society for the Promotion of Science; 24396 AFM-Téléthon; ANR-19-CE13-0008 Agence Nationale de la Recherche; TNE 15CVD01 Fondation Leducq; FDT2022040147500 Fondation pour la Recherche Médicale; 23K06316 Japan Society for the Promotion of Science; Institut National de la Santé et de la Recherche Médicale |
| فهرسة مساهمة: | Keywords: Head trunk interface; Mouse; Myogenesis; Neck muscle development; Retinoic acid signalling |
| المشرفين على المادة: | 5688UTC01R (Tretinoin) 0 (Receptors, Retinoic Acid) |
| تواريخ الأحداث: | Date Created: 20240731 Date Completed: 20240829 Latest Revision: 20240829 |
| رمز التحديث: | 20240831 |
| DOI: | 10.1242/dev.202905 |
| PMID: | 39082789 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9129 |
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| DOI: | 10.1242/dev.202905 |