دورية أكاديمية
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Major depressive disorder and perceived social support: Moderated mediation model of security and brain dysfunction.

التفاصيل البيبلوغرافية
العنوان: Major depressive disorder and perceived social support: Moderated mediation model of security and brain dysfunction.
المؤلفون: Luo Q; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, 510370, China., Xu Q; Department of Clinical Psychology, The Third Hospital of Longyan, 364000, China., Zhu L; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China., Liao J; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China., Xia J; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China., Lin X; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China., Peng H; Department of Clinical Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510370, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, 510370, China. Electronic address: pengdoctor2@163.com.
المصدر: Journal of psychiatric research [J Psychiatr Res] 2024 Sep; Vol. 177, pp. 392-402. Date of Electronic Publication: 2024 Jul 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Pergamon Press
مواضيع طبية MeSH: Depressive Disorder, Major*/physiopathology , Depressive Disorder, Major*/diagnostic imaging , Social Support* , Magnetic Resonance Imaging*, Humans ; Male ; Female ; Adult ; Middle Aged ; Brain/diagnostic imaging ; Brain/physiopathology ; Young Adult ; Connectome
مستخلص: Low social support increases the risk of Major depressive disorder (MDD), yet its effects on brain function are unclear. Thirty-two MDD patients with low social support, 52 with high social support, and 54 healthy controls were recruited. We investigated regional brain activity in MDD patients with low social support using resting-state functional Magnetic Resonance Imaging, employing measures such as degree centrality (DC), regional homogeneity, amplitude of low-frequency fluctuations, and fractional amplitude of low-frequency fluctuations. Abnormal regions identified in these analyses were selected as regions of interest for functional connectivity (FC) analysis. We then explored relationships among social support, brain dysfunction, MDD severity, and insecurity using partial correlation and moderated mediation models. Our findings reveal that MDD patients with low social support show decreased DC in the right superior temporal pole and right medial geniculate nucleus, coupled with increased FC between the right superior temporal pole and right inferior temporal gyrus, and the right supramarginal gyrus compared to those with high social support. Furthermore, the DC of the right medial geniculate nucleus positively correlates with social support, while the FC between the right superior temporal pole and right supramarginal gyrus negatively correlates with both social support and subjective support. Additionally, a moderated mediation model demonstrates that the FC between the right superior temporal pole and right supramarginal gyrus mediates the relationship between social support and depression severity, with security moderating this mediation. These findings underscore the impact of low social support on brain function and depression severity in MDD patients.
Competing Interests: Declaration of competing interest The authors declare no competing financial interests or potential conflicts of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Degree centrality; Functional connectivity; Major depressive disorder; Security; Social support
تواريخ الأحداث: Date Created: 20240731 Date Completed: 20240903 Latest Revision: 20240903
رمز التحديث: 20240904
DOI: 10.1016/j.jpsychires.2024.07.036
PMID: 39083997
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1379
DOI:10.1016/j.jpsychires.2024.07.036