دورية أكاديمية

Analysis of Immunobiological Properties of Recombinant Streptococcus pneumoniae Pneumolysin.

التفاصيل البيبلوغرافية
العنوان: Analysis of Immunobiological Properties of Recombinant Streptococcus pneumoniae Pneumolysin.
المؤلفون: Vorobyev DS; I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. vorobievdenis@yandex.ru., Petukhova ES; I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia., Volokh YV; I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia., Semenova IB; I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Aug 01. Date of Electronic Publication: 2024 Aug 01.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مستخلص: We compared the immunogenicity of recombinant S. pneumoniae pneumolysin (rPly) when administered with and without Al(OH) 3 adjuvant, and evaluated the protective properties of recombinant protein in the active defense experiment. It was shown that double immunization with rPly+Al(OH) 3 increases the levels of IgG antibodies in comparison with the control (p<0.01), while triple immunization results in a more significant increase in IgG antibody levels (p<0.001). Double immunization with rPly without Al(OH) 3 does not induce a significant increase in antibody levels in comparison with the control, while triple immunization results in a slight but significant increase in antibody levels (p<0.05). The active defense test proved the protective activity of rPly against S. pneumoniae serotype 3 at intranasal infection.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Streptococcus pneumoniae; aluminum hydroxide; antibody level; protective activity; recombinant pneumolysin
تواريخ الأحداث: Date Created: 20240801 Latest Revision: 20240801
رمز التحديث: 20240802
DOI: 10.1007/s10517-024-06166-0
PMID: 39090461
قاعدة البيانات: MEDLINE