دورية أكاديمية
Melanocyte lineage dynamics in development, growth and disease.
| العنوان: | Melanocyte lineage dynamics in development, growth and disease. |
|---|---|
| المؤلفون: | Brombin A; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK.; Edinburgh Cancer Research, CRUK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK., Patton EE; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK.; Edinburgh Cancer Research, CRUK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK. |
| المصدر: | Development (Cambridge, England) [Development] 2024 Aug 01; Vol. 151 (15). Date of Electronic Publication: 2024 Aug 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Eng : Company Of Biologists Limited Original Publication: [Cambridge] : Company of Biologists, [c1987- |
| مواضيع طبية MeSH: | Melanocytes*/metabolism , Melanocytes*/cytology , Cell Lineage* , Cell Differentiation* , Melanoma*/pathology , Melanoma*/metabolism , Melanoma*/genetics, Humans ; Animals ; Neural Crest/metabolism ; Cell Proliferation ; Skin Neoplasms/pathology ; Skin Neoplasms/metabolism ; Skin Neoplasms/genetics |
| مستخلص: | Melanocytes evolved to produce the melanin that gives colour to our hair, eyes and skin. The melanocyte lineage also gives rise to melanoma, the most lethal form of skin cancer. The melanocyte lineage differentiates from neural crest cells during development, and most melanocytes reside in the skin and hair, where they are replenished by melanocyte stem cells. Because the molecular mechanisms necessary for melanocyte specification, migration, proliferation and differentiation are co-opted during melanoma initiation and progression, studying melanocyte development is directly relevant to human disease. Here, through the lens of advances in cellular omic and genomic technologies, we review the latest findings in melanocyte development and differentiation, and how these developmental pathways become dysregulated in disease. Competing Interests: Competing interests E.E.P. is the Editor-in-Chief at Disease Models & Mechanisms published by The Company of Biologists, but was not included in any aspect of the editorial handling of this article or peer-review process. (© 2024. Published by The Company of Biologists Ltd.) |
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| معلومات مُعتمدة: | MC_UU_00035/13 United Kingdom MRC_ Medical Research Council; United States MRA Melanoma Research Alliance; 687306 Rosetrees Trust; CTRQQR-2021\100006 United Kingdom CRUK_ Cancer Research UK; University of Edinburgh |
| فهرسة مساهمة: | Keywords: Genomics; MITF; Melanocyte stem cells; Melanocytes; Melanoma; Multi-omics; Neural crest; Pigmentary disease; Pigmentation; Schwann cell precursor; Transcriptomics; scRNA-sequencing |
| تواريخ الأحداث: | Date Created: 20240802 Date Completed: 20240802 Latest Revision: 20240813 |
| رمز التحديث: | 20240813 |
| مُعرف محوري في PubMed: | PMC11317096 |
| DOI: | 10.1242/dev.201266 |
| PMID: | 39092608 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9129 |
|---|---|
| DOI: | 10.1242/dev.201266 |