دورية أكاديمية
Dietary protein affects tissue accumulation of mercury and induces hepatic Phase I and Phase II enzyme expression after co-exposure with methylmercury in mice.
| العنوان: | Dietary protein affects tissue accumulation of mercury and induces hepatic Phase I and Phase II enzyme expression after co-exposure with methylmercury in mice. |
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| المؤلفون: | Mellingen RM; Department of Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway; Department of Biomedicine, University of Bergen, Norway., Rasinger JD; Department of Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway., Nøstbakken OJ; Department of Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway., Myrmel LS; Department of Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway., Bernhard A; Department of Seafood, Nutrition and Environmental State, Institute of Marine Research, Bergen, Norway. Electronic address: Annette.Bernhard@hi.no. |
| المصدر: | The Journal of nutritional biochemistry [J Nutr Biochem] 2024 Nov; Vol. 133, pp. 109712. Date of Electronic Publication: 2024 Jul 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1996->: New York, NY : Elsevier Science Original Publication: Stoneham, MA, USA : Butterworths, c1990- |
| مواضيع طبية MeSH: | Methylmercury Compounds*/metabolism , Liver*/metabolism , Liver*/drug effects , Mice, Inbred BALB C* , Dietary Proteins*/metabolism, Animals ; Male ; Mercury/metabolism ; Mice ; Chickens ; Gastrointestinal Microbiome/drug effects ; Dietary Exposure/adverse effects ; Diet |
| مستخلص: | Methylmercury (MeHg) is a ubiquitous environmental contaminant, well known for its neurotoxic effects. MeHg can interact with several nutrients in the diet and affect nutrient metabolism, however the interaction between MeHg and dietary proteins has not been thoroughly investigated. Male BALB/c mice were fed diets based on either casein, cod or chicken as protein sources, which were or were not spiked with MeHg (3.5 mg Hg kg -1 ). Following 13 weeks of dietary exposure to MeHg, the animals accumulated mercury in a varying degree depending on the diet, where the levels of mercury were highest in the mice fed casein and MeHg, lower in mice fed cod and MeHg, and lowest in mice fed chicken and MeHg in all tissues assessed. Assessment of gut microbiota revealed differences in microbiota composition based on the different protein sources. However, the introduction of MeHg eliminated this difference. Proteomic profiling of liver tissue uncovered the influence of the dietary protein sources on a range of enzymes related to Phase I and Phase II detoxification mechanisms, suggesting an impact of the diet on MeHg metabolism and excretion. Also, enzymes linked to pathways including methionine and glycine betaine cycling, which in turn impact the production of glutathione, an important MeHg conjugation molecule, were up-regulated in mice fed chicken as dietary protein. Our findings indicate that dietary proteins can affect expression of hepatic enzymes that potentially influence MeHg metabolism and excretion, highlighting the relevance of considering the dietary composition in risk assessment of MeHg through dietary exposure. Competing Interests: Declaration of competing interests The authors declare no conflict of interest. The author JD Rasinger declares that he is currently employed with the European Food Safety Authority (EFSA) in the Food Ingredients and Packaging Unit (FIP), which provides scientific and administrative support to the Panel on Food Additives and Flavourings. However, the present article is published under the sole responsibility of the author JD Rasinger and may not be considered as an EFSA scientific output. The positions and opinions presented in this article are those of the author alone and are not intended to represent the views/any official position of EFSA. To know about the views or scientific outputs of EFSA, please consult its website. The author's main contributions to this article were made before joining EFSA when still employed at the Institute of Marine Research. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Phase I; Phase II; diet-nutrient-interaction; dietary exposure; dietary protein; methylmercury; proteomics |
| المشرفين على المادة: | 0 (Methylmercury Compounds) 0 (Dietary Proteins) FXS1BY2PGL (Mercury) |
| تواريخ الأحداث: | Date Created: 20240802 Date Completed: 20240908 Latest Revision: 20240908 |
| رمز التحديث: | 20240909 |
| DOI: | 10.1016/j.jnutbio.2024.109712 |
| PMID: | 39094928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4847 |
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| DOI: | 10.1016/j.jnutbio.2024.109712 |