دورية أكاديمية
أعرض في EDS

Epidemiological trends and treatment abandonment of paediatric solid tumours in a nigerian tertiary hospital: a seven-year review (2016-2022).

التفاصيل البيبلوغرافية
العنوان: Epidemiological trends and treatment abandonment of paediatric solid tumours in a nigerian tertiary hospital: a seven-year review (2016-2022).
المؤلفون: Nri-Ezedi CA; Department of Paediatrics, Nnamdi Azikiwe University, Awka, Anambra, Nigeria., Ulasi TO; Department of Paediatrics, Nnamdi Azikiwe University, Awka, Anambra, Nigeria., Menkiti FE; Department of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe University, Awka, Anambra, Nigeria. fe.menkiti@unizik.edu.ng., Ndukwe CO; Department of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe University, Awka, Anambra, Nigeria., Igwenagu CM; Department of Industrial Mathematics and Applied Statistics, Enugu State University of Science and Technology, Enugu, Nigeria., Akpuaka FC; Department of Surgery, Chukwuemeka Odumegwu Ojukwu University, Igbariam, Anambra, Nigeria.
المصدر: BMC cancer [BMC Cancer] 2024 Aug 02; Vol. 24 (1), pp. 943. Date of Electronic Publication: 2024 Aug 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Tertiary Care Centers*/statistics & numerical data , Neoplasms*/epidemiology , Neoplasms*/therapy, Humans ; Nigeria/epidemiology ; Male ; Female ; Child ; Retrospective Studies ; Child, Preschool ; Adolescent ; Infant ; Prevalence ; Treatment Outcome
مستخلص: Background: Paediatric solid tumours, both benign and malignant, present significant health challenges, particularly in Sub-Saharan Africa where comprehensive data is limited. This study aims to elucidate the prevalence, distribution, and treatment outcomes of paediatric solid neoplasms in a tertiary hospital in South-East Nigeria over a seven-year period.
Methods: A retrospective cohort study was conducted at Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria. Clinical details and histological slides of confirmed cases from January 2016 to December 2022 were reviewed. Data extraction focused on socio-demographic variables and treatment outcomes, analysed using statistical methods.
Results: The study included 293 children diagnosed with solid tumours (58.1% malignant, 41.9% benign), with a female predominance (61.8%). The median age at diagnosis was 12 years. Fibroadenoma was the most common benign tumour (61.8% of benign cases), while non-Hodgkin lymphoma was the predominant malignant tumour (18.2% of malignant cases). Treatment abandonment rates differed significantly between benign (13.8%) and malignant (51.2%) tumours. Significant associations were found between treatment outcomes and factors such as gender (p = 0.0001 for benign tumours), age category (p = 0.0001 for benign tumours), and specific diagnoses (p = 0.0001 for both benign and malignant tumours).
Conclusion: This study underscores the substantial burden of paediatric solid tumours in South-East Nigeria and highlights the critical need for improved treatment adherence strategies, particularly for malignant cases. The findings emphasize the importance of tailored interventions based on tumour type, age, and gender. These insights can inform future research, policy formulation, and healthcare strategies aimed at enhancing the management and outcomes of paediatric solid neoplasms in resource-limited settings.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Epidemiology; Neoplasm prevalence; Nigeria; Paediatric solid tumours; Retrospective study; Treatment adherence
تواريخ الأحداث: Date Created: 20240802 Date Completed: 20240803 Latest Revision: 20240805
رمز التحديث: 20240805
مُعرف محوري في PubMed: PMC11295635
DOI: 10.1186/s12885-024-12723-7
PMID: 39095784
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2407
DOI:10.1186/s12885-024-12723-7