دورية أكاديمية
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Biofabrication of aminated nanocellulose reinforced polyvinyl alcohol/chitosan nanofibrous scaffold for sustained release of diltiazem hydrochloride.

التفاصيل البيبلوغرافية
العنوان: Biofabrication of aminated nanocellulose reinforced polyvinyl alcohol/chitosan nanofibrous scaffold for sustained release of diltiazem hydrochloride.
المؤلفون: Samanta AP; Department of Jute and Fiber Technology, Institute of Jute Technology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, West Bengal, India; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, West Bengal, India., Ghosh A; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, West Bengal, India., Dutta K; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, West Bengal, India. Electronic address: koushikdutta.kaitha@gmail.com., Mandal D; Center for Research in Nanoscience and Nanotechnology, Acharya Prafulla Chandra Roy Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Saltlake City, Kolkata 700 098, WB, India., Tudu S; Center for Research in Nanoscience and Nanotechnology, Acharya Prafulla Chandra Roy Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Saltlake City, Kolkata 700 098, WB, India., Sarkar K; Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India., Das B; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, West Bengal, India., Ghosh SK; Department of Jute and Fiber Technology, Institute of Jute Technology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, West Bengal, India. Electronic address: ijtskg40@gmail.com., Chattopadhyay D; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, West Bengal, India; Center for Research in Nanoscience and Nanotechnology, Acharya Prafulla Chandra Roy Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Saltlake City, Kolkata 700 098, WB, India. Electronic address: dipankar.chattopadhyay@gmail.com.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 277 (Pt 3), pp. 134395. Date of Electronic Publication: 2024 Aug 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
مواضيع طبية MeSH: Chitosan*/chemistry , Polyvinyl Alcohol*/chemistry , Nanofibers*/chemistry , Cellulose*/chemistry , Diltiazem*/chemistry , Diltiazem*/pharmacology , Delayed-Action Preparations* , Drug Liberation*, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Animals ; Spectroscopy, Fourier Transform Infrared ; Drug Carriers/chemistry ; Biocompatible Materials/chemistry ; Tissue Scaffolds/chemistry
مستخلص: In the modern environment conscious era, there has been a huge demand for the effective green method to fabricate biomaterials for sustained transdermal release of diltiazem hydrochloride to treat hypertension and cardiac failure. In this vein, the present study explores the amination of waste jute sourced nanocellulose (ANC) and its effect as a reinforcing filler to design electrospun polyvinyl alcohol (PVA)/chitosan based polymeric nanofibrous scaffold for drug delivery. The characterization results of FTIR (Fourier Transform Infrared Spectroscopy) confirm the successful chemical modification of nanocellulose (NCC). SEM (Scanning Electron Microscopy) results indicate the morphological modifications in ANC due to grafting. ANC enhances the mechanical properties of scaffold and sustains the release of the loaded drug to 67.89±3.39% as compared to the pure PVA/chitosan scaffold of 92.63±4.63% over a period of 72 h as shown by the results of in-vitro drug release study. Moreover, the incorporation of 0.5 % ANC improves the anti-bacterial activity against both gram-positive (97.4±4.87%, reduction in viable cells count) and gram-negative bacteria (98.5±4.93%, reduction in viable cells count). Further, the skin irritation and MTT assay authenticate the biocompatibility of the developed scaffold. The overall findings hence prove the efficacy of the engineered scaffold as a potential transdermal patch for sustained drug delivery applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Electrospun nanofibrous composite; Surface modified nanocellulose; Transdermal drug delivery
المشرفين على المادة: 9012-76-4 (Chitosan)
9002-89-5 (Polyvinyl Alcohol)
9004-34-6 (Cellulose)
EE92BBP03H (Diltiazem)
0 (Delayed-Action Preparations)
0 (Anti-Bacterial Agents)
0 (Drug Carriers)
0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20240804 Date Completed: 20240904 Latest Revision: 20240904
رمز التحديث: 20240904
DOI: 10.1016/j.ijbiomac.2024.134395
PMID: 39098668
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0003
DOI:10.1016/j.ijbiomac.2024.134395