دورية أكاديمية
[Research on bitter taste and efficacy of Ginkgo biloba extract based on UPLC-Q-TOF-MS~E integrated with molecular docking].
| العنوان: | [Research on bitter taste and efficacy of Ginkgo biloba extract based on UPLC-Q-TOF-MS~E integrated with molecular docking]. |
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| المؤلفون: | Ge GB; Innovative Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China., Wu XY; Innovative Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China., Wang YJ; Innovative Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China., Hu JL; Innovative Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China., Tang B; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China Department of Pharmacy, Guangming Hospital of Traditional Chinese Medicine,Pudong New District, Shanghai 201399, China., Wu F; Innovative Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education Shanghai 201203, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2024 Jul; Vol. 49 (14), pp. 3784-3795. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Molecular Docking Simulation* , Ginkgo biloba*/chemistry , Taste* , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Tandem Mass Spectrometry*/methods, Chromatography, High Pressure Liquid/methods ; Humans ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Male ; Ginkgo Extract |
| مستخلص: | Based on high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS~E) and molecular docking technique, bitter compounds of Ginkgo biloba extract(GBE) were characterized, and their relationship with bitter efficacy was investigated. Firstly, UPLC-Q-TOF-MS~E was used for qualitative analysis of GBE components, and 60 chemical components were identified. These chemical components were molecular-docked with bitter receptors, and 26 bitter substances were selected, mainly flavonoids. Secondly, sensory and electronic tongue bitterness evaluation techniques were used to verify that total flavones of GBE were the main bitter substances, which was consistent with the molecular docking results. Finally, network pharmacology was used to predict and analyze bitter substances. The relationship between the target of bitter substance and bitter effect was explored. The key targets of bitter substances are CYP2B6, ALOX15, and PTGS2, etc., and bitter substances may exert a bitter efficacy by ac-ting on related disease targets, indicating that bitter substances of GBE are the material basis of the bitter effect. In summary, the study indicated that the molecular docking technique had a guiding effect on the screening of bitter substances in traditianal Chinese medicine(TCM), and bitter substances of GBE had a bitter efficacy. It provides ideas and references for the study of the "taste-efficacy relationship" of TCM in the future. |
| فهرسة مساهمة: | Keywords: "taste-efficacy" relationship; Ginkgo biloba extract; UPLC-Q-TOF-MS~E; bitter substance; bitterness evaluation; molecular docking; network pharmacology |
| المشرفين على المادة: | 0 (Plant Extracts) 19FUJ2C58T (Ginkgo biloba extract) 0 (Drugs, Chinese Herbal) 0 (Ginkgo Extract) |
| تواريخ الأحداث: | Date Created: 20240805 Date Completed: 20240805 Latest Revision: 20240805 |
| رمز التحديث: | 20240805 |
| DOI: | 10.19540/j.cnki.cjcmm.20231226.303 |
| PMID: | 39099352 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20231226.303 |